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Titolo:
Neuropeptide regulation of feeding in catfish, Ictalurus punctatus: a rolefor glucagon-like peptide-1 (GLP-1)?
Autore:
Silverstein, JT; Bondareva, VM; Leonard, JBK; Plisetskaya, EM;
Indirizzi:
USDA ARS, Catfish Genet Res Unit, Thad Cochran Natl Warmwater Aquaculture Ctr, Stoneville, MS 38776 USA USDA ARS Stoneville MS USA 38776 quaculture Ctr, Stoneville, MS 38776 USA IM Sechenov Evolutionary Physiol & Biochem Inst, St Petersburg 194223, Russia IM Sechenov Evolutionary Physiol & Biochem Inst St Petersburg Russia 194223 Univ Washington, Sch Fisheries, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Sch Fisheries, Seattle, WA 98195 USA
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
fascicolo: 2-3, volume: 129, anno: 2001,
pagine: 623 - 631
SICI:
1096-4959(200106)129:2-3<623:NROFIC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOOD-INTAKE REGULATION; GENE-EXPRESSION; BODY-WEIGHT; GOLDFISH BRAIN; FISH; BEHAVIOR; RECEPTOR; SATIETY; GROWTH;
Keywords:
feeding; feed intake regulation; glucagon-like peptide-1; intracerebroventricular injection; Exending(9-39); immunoneutralization; catfish; Ictalurus punctatus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Silverstein, JT USDA ARS, Catfish Genet Res Unit, Thad Cochran Natl Warmwater Aquaculture Ctr, Stoneville, MS 38776 USA USDA ARS Stoneville MS USA 38776 Stoneville, MS 38776 USA
Citazione:
J.T. Silverstein et al., "Neuropeptide regulation of feeding in catfish, Ictalurus punctatus: a rolefor glucagon-like peptide-1 (GLP-1)?", COMP BIOC B, 129(2-3), 2001, pp. 623-631

Abstract

Glucagon-like peptide 1 is a compound known to cause reduced food intake in mammals, though its action on feed intake in fish is unknown. The clear differences in the effects of GLP-1 on mammalian and teleostean glucose homeostasis suggest that we cannot assume a similar action of GLP-1 on feeding in mammals and fish. In this study the effects and specificity of centrallyadministered GLP-1 on feed intake were examined. It was demonstrated that intracerebroventricular (ICV) injection of glucagon-like peptide 1 (GLP-1) in the channel catfish (Ictalurus punctatus) is a potent inhibitor of feed intake with a dose of 0.25 ng g(-1) body wt. reducing feed intake by 50%. The weak response to intraperitoneal (i.p.) and intravenous (i.v.) injectiontreatments with GLP-1 suggests the major effects on feed intake are centrally mediated. GLP-1 action on feed intake was not antagonized by ICV injection of exendin(9-39). Immunoneutralization of GLP-1 by ICV injection of antisalmon GLP-1 antisera did not affect feed intake over 48 h, while ICV injection of GLP-1 at a dose of 30 ng g(-1) body wt. reduced feed intake for over 20 h. Additionally, there is some evidence that GLP-1 caused gastric evacuation. We conclude that GLP-1 is a potent inhibitor of feeding in fish, but its involvement in feed intake regulation under physiological conditionsremains to be clarified. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 06:12:23