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Titolo:
Fish gonadotropin and thyrotropin receptors: the evolution of glycoproteinhormone receptors in vertebrates
Autore:
Oba, Y; Hirai, T; Yoshiura, Y; Kobayashi, T; Nagahama, Y;
Indirizzi:
Natl Inst Basic Biol, Reprod Biol Lab, Okazaki, Aichi 4448585, Japan Natl Inst Basic Biol Okazaki Aichi Japan 4448585 ki, Aichi 4448585, Japan Teikyo Univ Sci & Technol, Dept Biosci, Uenohara 4440193, Japan Teikyo Univ Sci & Technol Uenohara Japan 4440193 Uenohara 4440193, Japan Teikyo Univ Sci & Technol, Biotechnol Res Ctr, Uenohara 4440193, Japan Teikyo Univ Sci & Technol Uenohara Japan 4440193 Uenohara 4440193, Japan
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
fascicolo: 2-3, volume: 129, anno: 2001,
pagine: 441 - 448
SICI:
1096-4959(200106)129:2-3<441:FGATRT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLICLE-STIMULATING-HORMONE; SALMON ONCORHYNCHUS-RHODURUS; PROTEIN-COUPLED RECEPTOR; LUTEINIZING-HORMONE; FUNCTIONAL-CHARACTERIZATION; GENOMIC ORGANIZATION; MOLECULAR-CLONING; SEA-ANEMONES; IN-VITRO; GTH-II;
Keywords:
evolution; glycoprotein hormone; gonadotropin receptor; salmonid; teleost; thyrotropin receptor; tilapia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Nagahama, Y Natl Inst Basic Biol, Reprod Biol Lab, Okazaki, Aichi 4448585,Japan Natl Inst Basic Biol Okazaki Aichi Japan 4448585 48585, Japan
Citazione:
Y. Oba et al., "Fish gonadotropin and thyrotropin receptors: the evolution of glycoproteinhormone receptors in vertebrates", COMP BIOC B, 129(2-3), 2001, pp. 441-448

Abstract

We have cloned and characterized, for the first time in fish, two different gonadotropin receptors (GTHR) and a single thyrotropin receptor (TSHR) from amago salmon (Oncorhynchus rhodurus) and Nile tilapia (Oreochromis niloticus). Phylogenetic analyses and intron/exon structure suggest that the twoGTHRs in fish are comparable to tetrapod follicle stimulating hormone and luteinizing hormone receptors. Temporal and spatial expression patterns, examined by Northern blot analysis and in situ hybridization, paralleled those seen in mammals and birds. Consequently, genetic and functional divergence of two GTHRs and TSHR probably occurred before the teleost and tetrapod split. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:43:14