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Titolo:
Regulation of gonadotropin beta subunit gene expression by testosterone and gonadotropin-releasing hormones in the goldfish, Carassius auratus
Autore:
Sohn, YC; Kobayashi, M; Aida, K;
Indirizzi:
Univ Tokyo, Grad Sch Agr & Life Sci, Dept Aquat Biosci, Bunkyo Ku, Tokyo 1138657, Japan Univ Tokyo Tokyo Japan 1138657 t Biosci, Bunkyo Ku, Tokyo 1138657, Japan
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
fascicolo: 2-3, volume: 129, anno: 2001,
pagine: 419 - 426
SICI:
1096-4959(200106)129:2-3<419:ROGBSG>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA LEVELS; SALMON ONCORHYNCHUS-KISUTCH; BASS MORONE-SAXATILIS; PITUITARY-CELLS; SEX STEROIDS; II-BETA; MOLECULAR-CLONING; FEEDBACK-CONTROL; ATLANTIC SALMON; GNRH;
Keywords:
follicle-stimulating hormone (FSH); gonadotropin-releasing hormone (GnRH); goldfish; gonadotropin (GTH); luteinizing hormone (LH); steroid; testosterone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Sohn, YC Chonnam Natl Univ, Ctr Ligand & Transcript, Kwangju 500757, SouthKorea Chonnam Natl Univ Kwangju South Korea 500757 00757, South Korea
Citazione:
Y.C. Sohn et al., "Regulation of gonadotropin beta subunit gene expression by testosterone and gonadotropin-releasing hormones in the goldfish, Carassius auratus", COMP BIOC B, 129(2-3), 2001, pp. 419-426

Abstract

Sex steroids differentially regulate gonadotropin (GTH) P subunits (FSH beta and LH beta) gene expression in the pituitary of goldfish: a strong in vivo inhibitory effect on FSH beta mRNA production, but a weak stimulatory effect on LH beta in sexually immature and recrudescent fish. In the presentstudy, to examine a direct effect of testosterone (T) and gonadotropin-releasing hormone (GnRH) on the mRNA levels of FSH beta and LH beta subunits in the pituitary, in vitro experiments were performed using dispersed pituitary cells of sexually immature, recrudescent, mature and regressed goldfish. T treatment in vitro did not significantly decrease FSH beta mRNA levels,but increased that of LH beta only in the cells of immature fish. Salmon-type GnRH increased FSH beta mRNA levels in cells of mature fish, but decreased the levels in cells of sexually regressed fish. From these results, it was suggested that: (1) in vivo effect of sex steroids on gene expression of GTH P subunits is not always exerted on the pituitary; and (2) the different responses of GTH P subunits by sex steroids between in vivo and in vitro are partly due to a complex pathway through hypothalamic factors, such asGnRH, in the case of in vivo. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 04/04/20 alle ore 14:52:39