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Titolo:
Insulin-like growth factor-I augments prolactin and inhibits growth hormone release through distinct as well as overlapping cellular signaling pathways
Autore:
Fruchtman, S; Gift, B; Howes, B; Borski, R;
Indirizzi:
N Carolina State Univ, Dept Zool, Raleigh, NC 27695 USA N Carolina State Univ Raleigh NC USA 27695 pt Zool, Raleigh, NC 27695 USA
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
fascicolo: 2-3, volume: 129, anno: 2001,
pagine: 237 - 242
SICI:
1096-4959(200106)129:2-3<237:IGFAPA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT ANTERIOR-PITUITARY; P70 S6 KINASE; TROUT ONCORHYNCHUS-MYKISS; PHOSPHATIDYLINOSITOL 3-KINASE; GENE-EXPRESSION; IGF-I; CELLS; SECRETION; ACTIVATION; SOMATOTROPH;
Keywords:
mitogen-activated protein kinase; phosphatidylinositol 3-kinase; IGF-I signal transduction; IGF-I receptor; LY294002; PD98059; rapamycin; pituitary; teleost;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Borski, R N Carolina State Univ, Dept Zool, Box 7617, Raleigh, NC 27695 USA N Carolina State Univ Box 7617 Raleigh NC USA 27695 NC 27695 USA
Citazione:
S. Fruchtman et al., "Insulin-like growth factor-I augments prolactin and inhibits growth hormone release through distinct as well as overlapping cellular signaling pathways", COMP BIOC B, 129(2-3), 2001, pp. 237-242

Abstract

We recently discovered a new role for insulin-like growth factor-I (IGF-I)as a specific and direct stimulator of prolactin (PRL) release in additionto its recognized function as an inhibitor of growth hormone (GH) release and synthesis. Little is known of the mechanisms that transduce the actionsof IGF-I on PRL and GH release in vertebrates. The present study was undertaken to determine the cellular pathways that mediate the disparate actionsof IGF-I on PRL and GH release in hybrid striped bass (Morone saxatilis X M. chrysops). When regulating cellular function, IGF-I may activate two primary pathways, phosphatidylinositol 3-kinase (PI 3-K) and mitogen-activatedprotein kinase (MAPK). The specific MAPK inhibitor, PD98059, blocked IGF-I-evoked PRL release as well as GH release inhibition over an 18-20-h incubation. LY294002, a specific PI 3-K inhibitor, overcame IGF-I's inhibition ofGH release but was ineffective in blocking PRL release stimulated by IGF-I. These studies suggest IGF-I disparately alters PRL and GH by activating distinct as well as overlapping signaling pathways central for mediating actions of growth factors on secretory activity as well as cell proliferation. These results further support a role for IGF-I as a physiological regulator of PRL and GH. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:46:18