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Titolo:
Tumor angiogenesis is associated with MUC1 overexpression and loss of prostate-specific antigen expression in prostate cancer
Autore:
Papadopoulos, I; Sivridis, E; Giatromanolaki, A; Koukourakis, MI;
Indirizzi:
Democritus Univ Thrace, Dept Urol, Larisa, Greece Democritus Univ Thrace Larisa Greece Thrace, Dept Urol, Larisa, Greece Democritus Univ Thrace, Dept Pathol, Larisa, Greece Democritus Univ Thrace Larisa Greece hrace, Dept Pathol, Larisa, Greece Univ Thessalia, Dept Radiotherapy & Oncol, Larisa, Greece Univ Thessalia Larisa Greece Dept Radiotherapy & Oncol, Larisa, Greece
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 6, volume: 7, anno: 2001,
pagine: 1533 - 1538
SICI:
1078-0432(200106)7:6<1533:TAIAWM>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL LUNG-CANCER; SERUM PSA; EXPERIENCE; CARCINOMA; MARKER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Papadopoulos, I Skoufa 3, Athens 14576, Greece Skoufa 3 Athens Greece 14576 ufa 3, Athens 14576, Greece
Citazione:
I. Papadopoulos et al., "Tumor angiogenesis is associated with MUC1 overexpression and loss of prostate-specific antigen expression in prostate cancer", CLIN CANC R, 7(6), 2001, pp. 1533-1538

Abstract

The biological potential of prostate cancer is highly variable and cannot be satisfactorily predicted by histopathological criteria alone. Therefore,additional and more precise information is desirable. Although angiogenesis has been suggested as being of prognostic importance in many human cancers, and MUC1, also known as episialin, was thought to be responsible for thedevelopment of metastasis, the role of these parameters in prostate cancerremains unclear. The aim of this study was to investigate whether angiogenesis, assessed as microvessel density (MVD), was correlated with the expression of prostate tumor MUC1 and prostate-specific antigen (PSA) or with histopathological grade at diagnosis, and to determine whether any of these factors might provide additional information with regard to prostate tumor biology. Paraffin-embedded material from 60 patients with prostate carcinoma was examined immunohistochemically, using the monoclonal antibody CD31 to determine MVD, and the monoclonal antibodies CCE831 and ER-PR8 to assess MUC1 and PSA expression, respectively. The tumors were categorized according to the Gleason grading system, MUC1 overexpression was significantly relatedto a high intratumoral angiogenesis (P = 0.02), By contrast, a high PSA expression by prostate cancer cells was associated with low MVD (P = 0.03), No correlation was found between MUC1 and PSA expression. Usually, high-grade tumors were not PSA-expressive and tended to display increased angiogenesis, These differences, however, were not of statistical significance. Similarly, there was no statistically significant association between histological grade and MUC1 expression or angiogenesis. It is suggested that PSA may have a direct suppressive effect on new blood vessel formation in prostate cancer, whereas the expression of MUC1 in this tumor may be connected with an angiogenic phenotype, Additional studies are obviously needed to clarifythe precise role of these proteins in prostate cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 19:45:10