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Titolo:
Pharmacogenetics: a new diagnostic tool in the management of antidepressive drug therapy
Autore:
Steimer, W; Muller, B; Leucht, S; Kissling, W;
Indirizzi:
Munich Univ Technol, Klinikum Rechts Isar, Inst Klin Chem & Pathobiochem, D-81675 Munich, Germany Munich Univ Technol Munich Germany D-81675 chem, D-81675 Munich, Germany Munich Univ Technol, Dept Psychiat & Psychotherapy, D-81675 Munich, Germany Munich Univ Technol Munich Germany D-81675 rapy, D-81675 Munich, Germany
Titolo Testata:
CLINICA CHIMICA ACTA
fascicolo: 1-2, volume: 308, anno: 2001,
pagine: 33 - 41
SICI:
0009-8981(200106)308:1-2<33:PANDTI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN TRANSPORTER GENE; OBSESSIVE-COMPULSIVE DISORDER; REUPTAKE INHIBITORS; CYP2D6 GENE; FUNCTIONAL POLYMORPHISM; EUROPEAN POPULATION; SWEDISH POPULATION; REGULATORY REGION; PROTEIN GENE; GENOTYPE;
Keywords:
pharmacogenetics; therapeutic drug monitoring; cytochrome P450 2D6 (CYP2D6); serotonin transporter polymorphism; tricyclic antidepressants (TCA); SSRI;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Steimer, W Munich Univ Technol, Klinikum Rechts Isar, Inst Klin Chem & Pathobiochem, Ismaninger Str 22, D-81675 Munich, Germany Munich Univ Technol Ismaninger Str 22 Munich Germany D-81675 y
Citazione:
W. Steimer et al., "Pharmacogenetics: a new diagnostic tool in the management of antidepressive drug therapy", CLIN CHIM A, 308(1-2), 2001, pp. 33-41

Abstract

Pharmacogenetics studies the genetic basis of an individual's ability to respond to pharmacotherapy. Variability of this response is a major problem. Fatal adverse drug reactions have been reported to be the fourth leading cause of death in the US. In depression. 30-40% of all patients do not respond sufficiently to the initial treatment and it can take up to 6 weeks for them to be identified. Much knowledge has been gathered throughout the last3 decades about the genetic basis of pharmacokinetic variability. Generic tests suitable for the routine laboratory are now available for some important metabolizing enzymes (e.g., CYP2D6, CYP2C19) identifying those individuals who are slow or fast metabolizers of certain drugs, many of which are widely used in the treatment of depression (e.g., tricyclic antidepressants). The possible use of these tests in the clinical practice of monitoring antidepressant therapy is discussed in relation to older phenotyping methods and therapeutic drug monitoring. Less well studied than the genetics of pharmacokinetics is the genetic basis of pharmacodynamic variability. As: selective serotonin reuptake inhibitors (SSRI) have a wide therapeutic index. pharmacokinetic variability usually does nor explain insufficient response to therapy. Recently. some excitement was caused by reports on serotonin transporter gene polymorphisms and their influence on the response to antidepressive therapy with SSRIs as this could provide an interesting diagnostic tool in assessing the chances of response to the: most popular group of antidepressants at present. Current knowledge in this young field of research is summarized. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 04/04/20 alle ore 09:15:11