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Titolo:
Short-term effects of radiotherapy on attention and memory performances inpatients with brain tumors
Autore:
Lilja, AM; Portin, RI; Hamalainen, PI; Salminen, EK;
Indirizzi:
Masku Neurol Rehabil Ctr, FIN-21251 Masku, Finland Masku Neurol Rehabil Ctr Masku Finland FIN-21251 IN-21251 Masku, Finland Univ Turku, Dept Psychol, Turku, Finland Univ Turku Turku FinlandUniv Turku, Dept Psychol, Turku, Finland Univ Turku, Dept Neurol, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 Dept Neurol, FIN-20520 Turku, Finland Turku Univ, Cent Hosp, Dept Radiotherapy & Oncol, FIN-20520 Turku, FinlandTurku Univ Turku Finland FIN-20520 apy & Oncol, FIN-20520 Turku, Finland
Titolo Testata:
CANCER
fascicolo: 12, volume: 91, anno: 2001,
pagine: 2361 - 2368
SICI:
0008-543X(20010615)91:12<2361:SEOROA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUALITY-OF-LIFE; HIGH-GRADE GLIOMA; MULTIPLE-SCLEROSIS; COGNITIVE FUNCTIONS; SURVIVORS; RADIATION; THERAPY; ADULTS; TRIAL;
Keywords:
brain tumor; radiotherapy; cognitive impairment; attention; memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Lilja, AM Masku Neurol Rehabil Ctr, POB 15, FIN-21251 Masku, Finland MaskuNeurol Rehabil Ctr POB 15 Masku Finland FIN-21251 Finland
Citazione:
A.M. Lilja et al., "Short-term effects of radiotherapy on attention and memory performances inpatients with brain tumors", CANCER, 91(12), 2001, pp. 2361-2368

Abstract

BACKGROUND. The objective of the current study was to evaluate the short-term effects of radiotherapy on attention and memory performance in patientswith brain tumors. METHODS. Thirteen patients underwent a neuropsychologic examination on three occasions: at baseline before radiotherapy, which lasted for 6 weeks; within 2 weeks after the completion of radiotherapy; and 3 months after the completion of radiotherapy. Thirty healthy individuals were studied at baseline as a control group. Verbal, visuomotor, and memory tests were administered. Attentional performances were examined using CogniSpeed((C)) reaction time software. RESULTS. At baseline, the patients scored significantly lower than the controls in tests of semantic memory (Similarities; P = 0.002), visuoconstructive skill (Block Design; P = 0.028), and visual and verbal memory (recall of 20 objects: immediate, P = 0.017; delayed, P = 0.002; recall of 30 pairedword associates: immediate, P = 0.002; delayed, P = 0.005). The patients performed significantly more poorly than the control group on the Two-ChoiceReaction Time test (P = 0.047), the Subtraction test (P = 0.042), and the Vigilance test (P = 0.023). After radiotherapy, the performance of the patients did not worsen on any measure, whereas their conscious cognitive processing was improved (P = 0.002). CONCLUSIONS. Treatment with radiotherapy did not cause negative short-termeffects on attentional and memory functions in patients with brain tumors who received a radiation dose of 54.5 grays. The cognitive deficits found in these patients were evident at baseline before radiotherapy. Thus, it seems likely that the deficits were associated with the tumor itself and/or the surgical procedures. (C) 2001 American Cancer Society.

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Documento generato il 23/01/20 alle ore 03:43:21