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Titolo:
Serial analysis of gene expression in the frontal cortex of patients with bipolar disorder
Autore:
Sun, YP; Zhang, L; Johnston, NL; Torrey, EF; Yolken, RH;
Indirizzi:
Johns Hopkins Univ, Sch Med, Stanley Div Dev Neurovirol, Baltimore, MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287 ovirol, Baltimore, MD 21287 USA Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 d Inst, Baltimore, MD 21205 USA Stanley Fdn Res Program, Bethesda, MD USA Stanley Fdn Res Program Bethesda MD USA dn Res Program, Bethesda, MD USA
Titolo Testata:
BRITISH JOURNAL OF PSYCHIATRY
, volume: 178, anno: 2001, supplemento:, 41
pagine: S137 - S141
SICI:
0007-1250(200106)178:<S137:SAOGEI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; SEROTONIN TRANSPORTER GENE; MESSENGER-RNA; SUSCEPTIBILITY; PROMOTER; ILLNESS; SUBUNIT; SCHIZOPHRENIA; PROFILES; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Yolken, RH Johns Hopkins Univ, Sch Med, Stanley Div Dev Neurovirol, 600 N Wolfe St,Blalock 1111, Baltimore, MD 21287 USA Johns Hopkins Univ 600 N Wolfe St,Blalock 1111 Baltimore MD USA 21287
Citazione:
Y.P. Sun et al., "Serial analysis of gene expression in the frontal cortex of patients with bipolar disorder", BR J PSYCHI, 178, 2001, pp. S137-S141

Abstract

Background Bipolar disorder is a serious brain disease affecting more thana million individuals living in the USA. Epidemiological studies indicate a role for both genetic and environmental factors in the pathogenesis of this disorder. Aim To identify RNA transcripts that are up- or down-regulated in the frontal cortex regions of individuals with bipolar disorder. Method Serial analysis of gene expression (SAGE) and reverse transcriptase-polymerase chain reaction were used to identify RNA transcripts which are differentially expressed in the frontal cortex of brains obtained postmortem from individuals with bipolar disorder compared with other psychiatric and control conditions. Results Levels of RNA transcripts encoding the serotonin transporter protein and components of the NF-kappaB transcription factor complex are significantly increased in individuals with bipolar disorder compared with unaffected controls. Increased levels of expression of these RNA transcripts were also detected in the brains of some individuals with schizophrenia and unipolar depression. Conclusion The SAGE technique offers promise for the characterisation of complex human brain diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 03:52:32