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Titolo:
The role of comparative genomic hybridisation in prenatal diagnosis
Autore:
Thein, A; Charles, A; Davies, T; Newbury-Ecob, R; Soothill, P;
Indirizzi:
Univ Bristol, St Michaels Hosp, Fetal Med Res Unit, Bristol BS8 1TH, Avon,England Univ Bristol Bristol Avon England BS8 1TH , Bristol BS8 1TH, Avon,England Southmead Hosp, Reg Cytogenet Dept, Lewis Lab, Bristol, Avon, England Southmead Hosp Bristol Avon England t, Lewis Lab, Bristol, Avon, England
Titolo Testata:
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
fascicolo: 6, volume: 108, anno: 2001,
pagine: 642 - 648
SICI:
1470-0328(200106)108:6<642:TROCGH>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-SITU HYBRIDIZATION; MOLECULAR CYTOGENETIC ANALYSIS; INSITU HYBRIDIZATION; SOLID TUMORS; AMPLIFICATION; ANEUPLOIDY; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Thein, A Univ Bristol, Fetal Med Res Unit, Southwell St, Bristol BS2 8EG, Avon, England Univ Bristol Southwell St Bristol Avon England BS2 8EG n, England
Citazione:
A. Thein et al., "The role of comparative genomic hybridisation in prenatal diagnosis", BR J OBST G, 108(6), 2001, pp. 642-648

Abstract

The aims of this study were to assess the feasibility of using comparativegenomic hybridisation instead of conventional cytogenetics in prenatal diagnosis and to determine the size of DNA loss that can be detected. Using comparative genomic hybridisation, six cases with standard aneuploidies were diagnosed correctly. This technique clearly identified a partial duplication of the long arm of chromosome 1 but was not capable of detecting the associated inversion. A small interstitial deletion on short arm of chromosome 10 also was detected precisely. Although the current comparative genomic hybridisation resolution is similar to the sensitivity of the highest resolution G banding, the latter is not a routine strategy in prenatal diagnosis. Comparative genomic hybridisation can allow full chromosome assessment equal to the highest resolution cytogenetic studies without the need for cell culture.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 22:14:34