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Titolo:
Premenopausal women affected by sexual arousal disorder treated with sildenafil: a double-blind, cross-over, placebo-controlled study
Autore:
Caruso, S; Intelisano, G; Lupo, L; Agnello, C;
Indirizzi:
Univ Catania, Dept Microbiol Sci & Gynaecol Sci, Grp Sexual Res, European Federat Sexol, I-95124 Catania, Italy Univ Catania Catania Italy I-95124 Federat Sexol, I-95124 Catania, Italy
Titolo Testata:
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
fascicolo: 6, volume: 108, anno: 2001,
pagine: 623 - 628
SICI:
1470-0328(200106)108:6<623:PWABSA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CLITORIS; SMOOTH-MUSCLE; DYSFUNCTION; ANDROGENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Caruso, S Osped S Bambino, Dept Microbiol & Gynaecol Sci, Via Torre Vescovo, I-95124Catania, Italy Osped S Bambino Via Torre Vescovo Catania Italy I-95124 , Italy
Citazione:
S. Caruso et al., "Premenopausal women affected by sexual arousal disorder treated with sildenafil: a double-blind, cross-over, placebo-controlled study", BR J OBST G, 108(6), 2001, pp. 623-628

Abstract

Objective To verify whether sildenafil is effective in young premenopausalwomen affected by arousal disorder. Design A double-blind cross-over study. Setting Centre for Sexological Research, Department of Microbiological andGynaecological Science, University of Catania, Italy. Sample Fifty-three volunteer women aged 22-28 years affected by arousal disorders. Methods The study consisted of three 4-week periods: sildenafil, washout, placebo, by six possible sequences. sildenafil was used at 25 mg or 50 mg. Main outcome measures Efficacy was assessed at baseline and once monthly by the Personal Experiences Questionnaire based on the 5-point Likert scale. The questionnaire quantified subjective arousal (primary endpoint), and orgasm, enjoyment, sexual frequency, and the number of sexual fantasies. Results Fifty-one women completed the study. Mean (SD) usage of sildenafil25mg and 50mg was, respectively, 2.8 (0.8) and 2.7 (1.3) times weekly, while mean usage of placebo was 2.8 (1.6) times weekly. During both sildenafildosages, arousal and orgasm improved with respect to placebo (P < 0.001). Therapeutically significant differences were not noted during the treatmentwith both 50 mg and 25 mg of sildenafil for arousal and orgasm. The frequency of sexual fantasies and of sexual intercourse, and enjoyment, improved in the women treated with sildenafil (P < 0.05). Conclusions Our study suggests that sildenafil may improve sexual performance of women affected by sexual difficulties such as arousal disorder, and may indirectly improve other aspects of sexual life. Moreover, further studies need to define the use of PDE type 5 inhibitors in this sexual pathophysiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 12:41:36