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Titolo:
Microvascular vasodilator response to acetylcholine is increased in women with pre-eclampsia
Autore:
Davis, KR; Ponnampalam, J; Hayman, R; Baker, PN; Arulkumaran, S; Donnelly, R;
Indirizzi:
Univ Nottingham, Div Vasc Med, Nottingham NG7 2RD, England Univ Nottingham Nottingham England NG7 2RD , Nottingham NG7 2RD, England Univ Nottingham, Dept Obstet & Gynaecol, Nottingham NG7 2RD, England Univ Nottingham Nottingham England NG7 2RD , Nottingham NG7 2RD, England
Titolo Testata:
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
fascicolo: 6, volume: 108, anno: 2001,
pagine: 610 - 614
SICI:
1470-0328(200106)108:6<610:MVRTAI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT RELAXATION; RESISTANCE ARTERIES; NITRIC-OXIDE; VASCULAR REACTIVITY; PREECLAMPSIA; PREGNANCY; IONTOPHORESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Donnelly, R Univ Nottingham, Derbyshire Royal Infirm, Div Vasc Med, Derby DE1 2QY, England Univ Nottingham Derby England DE1 2QY Derby DE1 2QY, England
Citazione:
K.R. Davis et al., "Microvascular vasodilator response to acetylcholine is increased in women with pre-eclampsia", BR J OBST G, 108(6), 2001, pp. 610-614

Abstract

Objectives To evaluate in vivo microvascular responses to incremental doses of the endothelial-dependent vasodilator, acetylcholine, and the endothelial-independent vasodilator, sodium nitroprusside, in women with pre-eclampsia and gestation-matched normotensive pregnant controls. Design Prospective clinical study. Setting Southern Derbyshire Acute Hospitals Trust, and University of Nottingham Division of Vascular Medicine. Population Thirteen women with pre-eclampsia and 16 normotensive pregnant controls. Methods Cutaneous microvascular vasodilator responses to iontophoretic administration of incremental doses of acetylcholine and sodium nitroprusside (25-100 muC) were evaluated under temperature-controlled conditions using laser Doppler fluximetry. Results Resting skin temperature and blood flow were similar among 13 women with pre-eclampsia [mean blood pressure 151/93 mmHg (4/3); mean gestation35.6 weeks (1.0); and mean proteinuria 1.1 g/24h (0.2)] and 16 normotensive pregnant controls [mean blood pressure 111/63 mmHg (2/2); mean gestation 34.3 weeks (0.9)]. Peak vasodilator responses to acetylcholine were increased in women with pre-eclampsia (median flux ratio 15.1 [IQR 12.3-17.6] vs 11.7 [IQR 8.4-12.6], P < 0.05), whereas sodium nitroprusside responses were not different between the two groups: 11.4 [IQR 8.6-13.4] vs 9.5 [IQR 8.0-12.3]. Conclusion In vivo microvascular vasodilator responses to acetylcholine are increased in women with preeclampsia, while endothelial-independent vasodilation is unchanged. Although the mechanism of acetylcholine induced vasodilation in small vessels is unclear, this study confirms previous animal data and provides in vivo evidence of altered microvascular endothelial cell function in pre-eclampsia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 02:11:02