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Titolo:
Conversion of cyclic nonaketides to lovastatin and compactin by a lovC deficient mutant of Aspergillus terreus
Autore:
Auclair, K; Kennedy, J; Hutchinson, CR; Vederas, JC;
Indirizzi:
Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada Univ Alberta Edmonton AB Canada T6G 2G2 hem, Edmonton, AB T6G 2G2, Canada Univ Wisconsin, Sch Pharm, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 sin, Sch Pharm, Madison, WI 53706 USA Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 Dept Bacteriol, Madison, WI 53706 USA Kosan Biosci Inc, Hayward, CA 94545 USA Kosan Biosci Inc Hayward CA USA 94545 n Biosci Inc, Hayward, CA 94545 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 12, volume: 11, anno: 2001,
pagine: 1527 - 1531
SICI:
0960-894X(20010618)11:12<1527:COCNTL>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
COENZYME-A REDUCTASE; HMG-COA REDUCTASE; COMPETITIVE INHIBITOR; OXYGEN-ATOMS; MONACOLIN-K; BIOSYNTHESIS; MEVINOLIN; ML-236B; ORIGIN; AGENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Vederas, JC Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada Univ Alberta Edmonton AB Canada T6G 2G2 n, AB T6G 2G2, Canada
Citazione:
K. Auclair et al., "Conversion of cyclic nonaketides to lovastatin and compactin by a lovC deficient mutant of Aspergillus terreus", BIOORG MED, 11(12), 2001, pp. 1527-1531

Abstract

Investigation of the post-PKS biosynthetic steps to the cholesterol-lowering agent lovastatin (1) using an Aspergillus terreus strain with a disrupted lovC gene, which is essential for formation of 4a,5-dihydromonacolin L (3), shows that 7 and 3 are precursors to 1, and demonstrates that lovastatindiketide synthase (lovF protein) does not require lovC. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 13:31:19