Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Regio-reactive resin: A platform for orthogonal loading using the polymer backbone and cross-linker
Autore:
Dickerson, TJ; Reed, NN; Janda, KD;
Indirizzi:
Scripps Clin & Res Inst, Dept Chem, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 hem, La Jolla, CA 92037 USA Scripps Clin & Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 iol, La Jolla, CA 92037 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 12, volume: 11, anno: 2001,
pagine: 1507 - 1509
SICI:
0960-894X(20010618)11:12<1507:RRAPFO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHASE ORGANIC-SYNTHESIS; SOLID-PHASE; ENANTIOSELECTIVE EPOXIDATION; PEPTIDE-SYNTHESIS; ASYMMETRIC EPOXIDATION; MINIMAL PURIFICATION; POLYSTYRENE RESINS; SUPPORTS; OLEFINS; CATALYST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Janda, KD Scripps Clin & Res Inst, Dept Chem, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA Scripps Clin & Res Inst 10550 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
T.J. Dickerson et al., "Regio-reactive resin: A platform for orthogonal loading using the polymer backbone and cross-linker", BIOORG MED, 11(12), 2001, pp. 1507-1509

Abstract

A new support for solid-phase combinatorial organic synthesis has been developed, which we term a regio-reactive resin (R-3-resin). The resin is based on a unique hydroxyl-functionalized cross-linker readily synthesized in two steps starting from 4-hydroxybenzaldehyde. The cross-linker's ease of synthesis and high purity enables the preparation of gel-type resins with regio-reactive orthogonal loading sites. The resin's swelling properties were investigated, and its potential utility was demonstrated via orthogonal reactivity of the pendant and cross-linker sites. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/08/20 alle ore 14:39:04