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Titolo:
The insulin-sensitive GLUT4 storage compartment is a postendocytic and heterogeneous population recruited by acute exercise
Autore:
Tomas, E; Sevilla, L; Palacin, M; Zorzano, A;
Indirizzi:
Univ Barcelona, Fac Biol, Dept Bioquim & Biol Mol, Barcelona, Spain Univ Barcelona Barcelona Spain ept Bioquim & Biol Mol, Barcelona, Spain
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 2, volume: 284, anno: 2001,
pagine: 490 - 495
SICI:
0006-291X(20010608)284:2<490:TIGSCI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOSE-TRANSPORTER GLUT4; RAT SKELETAL-MUSCLE; 3T3-L1 ADIPOCYTES; CELL-SURFACE; TRAFFICKING; TRANSLOCATION; LOCALIZATION; PROTEIN; IDENTIFICATION; CONTRACTIONS;
Keywords:
GLUT4 traffic; transferrin receptor; IGF-II receptor; skeletal muscle rat; insulin; exercise;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Tomas, E Evans Biomed Res Ctr, Diabet & Metab Unit, 650 Albany St, Boston,MA 02118USA Evans Biomed Res Ctr 650 Albany St Boston MA USA 02118 A 02118USA
Citazione:
E. Tomas et al., "The insulin-sensitive GLUT4 storage compartment is a postendocytic and heterogeneous population recruited by acute exercise", BIOC BIOP R, 284(2), 2001, pp. 490-495

Abstract

Insulin and acute exercise stimulate glucose transport in skeletal muscle by translocating GLUT4 glucose transporters to the cell surface. GLUT4 is distributed in skeletal muscle in two intracellular membrane populations, anendosomal pool that remains unaltered after insulin treatment and an storage population that is markedly GLUT4 depleted in response to insulin. Here we have further characterized the storage GLUT4 compartment in regard to protein composition and sensitivity to acute exercise. This GLUT4 compartmentcontained IRAP (insulin-regulated aminopeptidase), transferrin receptors or mannose-6-phosphate/IGF-II receptors, indicating a postendocytic origin. Insulin administration caused a depletion of GLUT4 and IRAP but no changes in transferrin receptors, which suggests that this pool is heterogeneous. In addition, acute exercise caused a marked GLUT4 depletion in the storage compartment, whereas no changes were detected in the endosomal population. In all, our data indicate that the GLUT4 storage population represents a postendocytic and heterogeneous compartment; the storage compartment represents the recruitment site that triggers GLUT4 translocation to the cell surface in response to both insulin and acute exercise, (C) 2001 Academic Press.

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Documento generato il 27/11/20 alle ore 10:33:06