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Titolo:
Adaptor protein Lad relays PDGF signal to Grb2 in lung cells: A tissue-specific PDGF signal transduction
Autore:
Park, DS; Choi, YB; Han, MK; Kim, UH; Shin, JY; Yun, YD;
Indirizzi:
Ewha Womans Univ, Div Mol Life Sci, Seoul 120750, South Korea Ewha Womans Univ Seoul South Korea 120750 Sci, Seoul 120750, South Korea Ewha Womans Univ, Ctr Cell Signaling Res, Seoul 120750, South Korea Ewha Womans Univ Seoul South Korea 120750 Res, Seoul 120750, South Korea Chonbuk Natl Univ, Sch Med, Dept Biochem, Chonju 561182, South Korea Chonbuk Natl Univ Chonju South Korea 561182 , Chonju 561182, South Korea Chonbuk Natl Univ, Sch Med, Inst Med Sci, Chonju 561182, South Korea Chonbuk Natl Univ Chonju South Korea 561182 , Chonju 561182, South Korea Sung Kyun Kwan Univ, Sch Med, Suwon 440746, South Korea Sung Kyun Kwan Univ Suwon South Korea 440746 , Suwon 440746, South Korea
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 2, volume: 284, anno: 2001,
pagine: 275 - 281
SICI:
0006-291X(20010608)284:2<275:APLRPS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR RECEPTOR; FACTOR ALPHA-RECEPTOR; FACTOR BETA-RECEPTOR; EPITHELIAL-CELLS; BINDING-SITES; ACTIVATION; EXPRESSION; DOMAIN; MOLECULES; CLONING;
Keywords:
Lad; adaptor protein; PDGF signaling; Grb2; lung cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Yun, YD Ewha Womans Univ, Div Mol Life Sci, Seoul 120750, South Korea EwhaWomans Univ Seoul South Korea 120750 ul 120750, South Korea
Citazione:
D.S. Park et al., "Adaptor protein Lad relays PDGF signal to Grb2 in lung cells: A tissue-specific PDGF signal transduction", BIOC BIOP R, 284(2), 2001, pp. 275-281

Abstract

Lad was previously identified as an adaptor protein binding to the SH2 domain of Lck (1). Specific detection of Lad mRNA in lung cells, as well as, in T cells led us to investigate the signaling pathways regulating Lad in lung cells. We found that (i) upon PDGF stimulation, Lad expression is induced in lung cells, especially in the bronchial epithelial cells; (ii) Lad is tyrosine phosphorylated upon PDGF stimulation and is associated with PDGF receptor; (iii) upon PDGF stimulation, Grb2 is recruited to Lad in human embryonic lung cells; (iv) overexpression of Lad elevated AP-1 promoter activity by two- to threefold, whereas dominant negative Lad abrogated PDGF-dependent activation of AP-1 promoter. These results provide a novel mechanism of PDGF-dependent signaling, in which Lad acts as an adaptor in a tissue-specific manner, linking PDGF signal to Grb2 and subsequent activation of AP-1. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 16:49:13