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Titolo:
Preferential expression of reg I beta gene in human adult pancreas
Autore:
Sanchez, D; Figarella, C; Marchand-Pinatel, S; Bruneau, N; Guy-Crotte, O;
Indirizzi:
Fac Med Marseille, Grp Rech Glandes Exocrines, F-13385 Marseille 5, FranceFac Med Marseille Marseille France 5 crines, F-13385 Marseille 5, France Fac Med Marseille, INSERM, U559, F-13385 Marseille, France Fac Med Marseille Marseille France F-13385 59, F-13385 Marseille, France
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 3, volume: 284, anno: 2001,
pagine: 729 - 737
SICI:
0006-291X(20010615)284:3<729:PEORIB>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONOBESE DIABETIC MOUSE; HUMAN FETAL PANCREAS; ACTIVE DIABETOGENESIS; NUCLEOTIDE-SEQUENCE; SECRETORY PROTEIN; MESSENGER-RNAS; STONE PROTEIN; CELL-LINE; PRODUCT; TISSUES;
Keywords:
pancreas; human; fetus; adult; regs; genes expression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Sanchez, D Fac Med Marseille, Grp Rech Glandes Exocrines, 27 Blvd Jean Moulin, F-13385 Marseille 5, France Fac Med Marseille 27 Blvd Jean Moulin Marseille France 5 rance
Citazione:
D. Sanchez et al., "Preferential expression of reg I beta gene in human adult pancreas", BIOC BIOP R, 284(3), 2001, pp. 729-737

Abstract

In human pancreas two genes, reg I alpha and reg I beta, have been characterized but only the reg I alpha protein has been isolated from human pancreatic secretion. To examine their respective physiological roles in fetal and adult pancreas we have compared the patterns of gene expression using a specific RT-PCR method. No progressive evolution in the two mRNAs levels wasobserved during fetal development (16-41 weeks). A discoordinate expression of the two genes was found with a higher level of reg I alpha mRNA in fetus and a higher level of regI beta in adult. In addition, if reg I alpha mRNA level was correlated with the expression of genes encoding exocrine proteins in adults, reg I beta mRNA level presented no correlation with any ductular, endocrine, or exocrine gene expression. In human pancreatic cell lines we showed the only expression of reg I beta gene and protein. All these data suggest that the two reg genes and proteins could play different rolesin the pancreas. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 13:38:42