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Titolo:
Gastric mucosal morphological consequences of acid suppression: a balancedview
Autore:
Meuwissen, SGM; Craanen, ME; Kuipers, EJ;
Indirizzi:
Vrije Univ Amsterdam, Med Ctr, Dept Gastroenterol, Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands erol, Amsterdam, Netherlands Acad Hosp Dijkzigt, Dept Gastroenterol & Hepatol, NL-3000 DR Rotterdam, Netherlands Acad Hosp Dijkzigt Rotterdam Netherlands NL-3000 DR tterdam, Netherlands
Titolo Testata:
BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY
fascicolo: 3, volume: 15, anno: 2001,
pagine: 497 - 510
SICI:
1521-6918(200106)15:3<497:GMMCOA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HELICOBACTER-PYLORI INFECTION; GASTROESOPHAGEAL REFLUX DISEASE; TERM OMEPRAZOLE THERAPY; PROTON PUMP INHIBITOR; VITAMIN-C LEVELS; PARIETAL-CELL PROTRUSIONS; DUODENAL-ULCER PATIENTS; N-NITROSO COMPOUNDS; ATROPHIC GASTRITIS; BACTERIAL OVERGROWTH;
Keywords:
Helicobacter pylori; gastric corpus; gastric antrum; gastric mucosa; atrophic gastritis; proton pump inhibitor; omeprazole; gastro-oesophageal reflux disease;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
103
Recensione:
Indirizzi per estratti:
Indirizzo: Meuwissen, SGM Vrije Univ Amsterdam, Med Ctr, Dept Gastroenterol, De Boelelaan 1085, Amsterdam, Netherlands Vrije Univ Amsterdam De Boelelaan 1085 Amsterdam Netherlands
Citazione:
S.G.M. Meuwissen et al., "Gastric mucosal morphological consequences of acid suppression: a balancedview", BEST PR RES, 15(3), 2001, pp. 497-510

Abstract

In the chapter, an analysis of the literature on the relationship between Helicobacter pylori. the use of proton pump inhibitors and the development of atrophic gastritis is presented, and the difficulties of classifying gastritis and the new possibilities of quantifying chronic inflammation by morphometric analysis are discussed. The issue surrounding the necessity of eradicating H. pylori in H. pylori-positive patients has still not been solved, Most studies have now accepted that proton pump inhibitors indeed accelerate the onset of atrophic gastritis in H. pylori-positive patients, but evidence against such an association was published in one recent (Scandinavian) study; conclusions from this study have, however, been challenged by several groups. Some data are available on the efficacy of H. pylori eradication with regard to the prevention of atrophy. The limited significance of the development of parietal cell protrusions and fundic gland cysts is betterunderstood, but much less is known of the development and long-term consequence of H. pylori-induced autoimmune gastritis. Finally, recent studies inH. pylori-positive patients indicate that treatment with proton pump inhibitors may promote bacterial N-nitrosation formation. These data taken together suggest that the eradication of H. pylori may be based not only on morphological arguments. but also on bacterial alterations in the gastric milieu.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:54:50