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Titolo:
Role of acid suppressants in prophylaxis of NSAID damage
Autore:
Chan, FKL; Sung, JJY;
Indirizzi:
Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China Chinese Univ Hong Kong Hong Kong Hong Kong Peoples R China oples R China
Titolo Testata:
BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY
fascicolo: 3, volume: 15, anno: 2001,
pagine: 433 - 445
SICI:
1521-6918(200106)15:3<433:ROASIP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ANTI-INFLAMMATORY DRUGS; HIGH-DOSE RANITIDINE; RAT GASTRIC-MUCOSA; PEPTIC-ULCER; RHEUMATOID-ARTHRITIS; DUODENAL-ULCERS; DOUBLE-BLIND; CONTROLLED TRIAL; INTRAGASTRIC PH;
Keywords:
non-steroidal anti-inflammatory drugs; ulcer; acid suppression; proton pump inhibitors; H-2-receptor antagonists; misoprostol; Helicobacter pylori;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Chan, FKL Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut,Hong Kong, Hong Kong, Peoples R China Chinese Univ Hong Kong Hong Kong Hong Kong Peoples R China ina
Citazione:
F.K.L. Chan e J.J.Y. Sung, "Role of acid suppressants in prophylaxis of NSAID damage", BEST PR RES, 15(3), 2001, pp. 433-445

Abstract

Gastric acid contributes to the pathogenesis of non-steroidal anti-inflammatory drug (NSAID)induced ulceration via several mechanisms, including conversion of superficial to deeper injury, impairment of haemostasis, and interference with ulcer healing. The suppression of acid secretion has been shown to reduce the severity of NSAID-induced mucosal damage in experimental models and clinical studies. Current evidence indicates that proton pump inhibitors (PPIs) are the preferred treatment for the healing of gastric ulcers when NSAIDs cannot be discontinued. PPIs are superior to standard-dose H-2-receptor antagonists and equivalent to low-dose misoprostol in preventingNSAID-induced gastric ulcers. Whether there is any significant advantage of PPIs over higher doses of H-2-receptor antagonists or misoprostol is unknown. The efficacy of PPIs is enhanced in the presence of H. Pylori infection. Omeprazole has been shown to be effective for the secondary prevention of ulcer bleeding in H. pylori-infected NSAID users. The efficacy of PPIs for the prevention of ulcer complications in H. pylori-negative NSAID users remains uncertain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:11:14