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Titolo:
Histamine receptor antagonists, proton pump inhibitors and their combination in the treatment of gastro-oesophageal reflux disease
Autore:
Katz, PO; Tutuian, R;
Indirizzi:
Univ Penn, Grad Hosp, Dept Med, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Dept Med, Philadelphia, PA 19104 USA
Titolo Testata:
BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY
fascicolo: 3, volume: 15, anno: 2001,
pagine: 371 - 384
SICI:
1521-6918(200106)15:3<371:HRAPPI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTROESOPHAGEAL REFLUX; BARRETTS-ESOPHAGUS; ACID BREAKTHROUGH; MEDICAL THERAPY; 20 MG; OMEPRAZOLE; RANITIDINE; PH; LANSOPRAZOLE; SYMPTOMS;
Keywords:
gastro-oesophageal reflux; proton pump inhibitors; histamine blockers; nocturnal acid breakthrough;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Katz, PO Univ Penn, Grad Hosp, Dept Med, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 , Philadelphia, PA 19104 USA
Citazione:
P.O. Katz e R. Tutuian, "Histamine receptor antagonists, proton pump inhibitors and their combination in the treatment of gastro-oesophageal reflux disease", BEST PR RES, 15(3), 2001, pp. 371-384

Abstract

The medical treatment of gastro-oesophageal reflux disease is accomplishedwith the appropriate use of anti-secretory therapy, principally H-2-receptor antagonists and proton pump inhibitors. In fact, there is a direct correlation between the length of time, in terms of the number of hours per day that the intragastric pH is above 4, and the healing of the oesophagitis. Nowadays, H-2-receptor antagonists are of limited use as primary treatment, being inferior to proton pump inhibitors in both healing and symptom relief. Although the majority of patients can be effectively managed with carefully titrated doses of proton pump inhibitors. a small number will continue to show difficulty in the management of their disease, principally because of inadequate nocturnal acid control. These patients may benefit from a combination of proton pump inhibitors twice daily with an H-2-receptor antagonist at bedtime. This article reviews the use of H-2-antagonists, proton pumpinhibitors and their combination in the management of the patient with gastro-oesophageal reflux disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 17:27:22