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Titolo:
Effect of the beta(2)-agonist clenbuterol on the locomotor activity of ratsubmitted to a 14-day period of hypodynamia-hypokinesia
Autore:
Canu, MH; Stevens, L; Ricart-Firinga, C; Picquet, F; Falempin, M;
Indirizzi:
Univ Sci & Tech Lille Flandres Artois, Lab Plast Neuromusculaire, F-59655 Villeneuve Dascq, France Univ Sci & Tech Lille Flandres Artois Villeneuve Dascq France F-59655 ce
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1, volume: 122, anno: 2001,
pagine: 103 - 112
SICI:
0166-4328(200107)122:1<103:EOTBCO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL-MUSCLE FIBERS; CENTRAL NERVOUS-SYSTEM; SOLEUS MUSCLE; HINDLIMB SUSPENSION; TREADMILL LOCOMOTION; MEDIAL GASTROCNEMIUS; BETA-ADRENOCEPTORS; BODY-COMPOSITION; TRICEPS SURAE; SPINAL-CORD;
Keywords:
electromyography; soleus; gastrocnemius; atrophy; beta(2)-adrenergic agonist; microgravity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Canu, MH Univ Sci & Tech Lille Flandres Artois, Lab Plast Neuromusculaire,Bat SN4,F-59655 Villeneuve Dascq, France Univ Sci & Tech Lille Flandres Artois Bat SN4 Villeneuve Dascq France F-59655
Citazione:
M.H. Canu et al., "Effect of the beta(2)-agonist clenbuterol on the locomotor activity of ratsubmitted to a 14-day period of hypodynamia-hypokinesia", BEH BRA RES, 122(1), 2001, pp. 103-112

Abstract

The beta (2)-adrenergic agonist clenbuterol is known for its anabolic action on normal and atrophied muscles. The aim of this work was to evaluate ifchronic clenbuterol administration could prevent alterations in the locomotor activity induced by hindlimb suspension. The effects of clenbuterol were evaluated in three studies: muscle morphological characteristics, observation of locomotor movement and electromyographic activity of soleus and gastrocnemius muscles. Rats were divided into four groups: control (CON, morphological study only), hindlimb suspended (HS), clenbuterol administered (CB, 2 mg kg(-1) per day in drinking water), and hindlimb suspended + clenbuterol administered (HSCB). The soleus muscle weight was reduced in the two suspended groups (HS and HSCB) but did not change after clenbuterol treatment. By contrast, the gastrocnemius weight was not affected by suspension but was increased by clenbuterol (CB and HSCB). Some locomotor deficits were always observed in HS rats (unstable gait, ankle hyperextension,...). Clenbuterol administration did not prevent these perturbations. Cycle duration andsoleus burst duration were increased in the three groups. Soleus mean EMG (burst area/duration) was decreased in HS rats, but not in the two other groups. For the gastrocnemius, burst duration was increased in CB rats, decreased in HSCB rats and unchanged in HS ones; mean EMG did not change. In conclusion: clenbuterol cannot be used as a countermeasure to reduce the alteration in locomotor performance. Moreover, our results suggest that this alteration is specifically related to changes in neuronal properties. (C) 2001Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 13:37:35