Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Dissociation of arousal-like from anxiogenic-like actions of brain corticotropin-releasing factor receptor ligands in rats
Autore:
Heinrichs, SC; Joppa, M;
Indirizzi:
Boston Coll, Dept Psychol, Chestnut Hill, MA 02467 USA Boston Coll Chestnut Hill MA USA 02467 ychol, Chestnut Hill, MA 02467 USA Neurocrine Biosci Inc, San Diego, CA 92121 USA Neurocrine Biosci Inc San Diego CA USA 92121 Inc, San Diego, CA 92121 USA
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1, volume: 122, anno: 2001,
pagine: 43 - 50
SICI:
0166-4328(200107)122:1<43:DOAFAA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-BINDING PROTEIN; FACTOR CRF; BEHAVIORAL-RESPONSES; STRESS; FEAR; NEUROBIOLOGY; WITHDRAWAL; UROCORTIN; PEPTIDES; AMYGDALA;
Keywords:
corticotropin-releasing factor; immobility; locomotor; aversion; anxiogenic rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Heinrichs, SC Boston Coll, Dept Psychol, McGuinn Hall,140 Commonwealth Ave, Chestnut Hill, MA 02467 USA Boston Coll McGuinn Hall,140 Commonwealth AveChestnut Hill MA USA 02467
Citazione:
S.C. Heinrichs e M. Joppa, "Dissociation of arousal-like from anxiogenic-like actions of brain corticotropin-releasing factor receptor ligands in rats", BEH BRA RES, 122(1), 2001, pp. 43-50

Abstract

Behavioral actions of centrally administered corticotropin-releasing factor (CRF) are likely subserved by multiple brain targets and functional effector systems. The present studies compared effects of two CRF ligands, a full, post-synaptic CRF receptor agonist (rat/human CRF(1-41)) and a CRF binding protein ligand inhibitor (rat/human CRF(6-33)) in a behavioral testing battery sensitive to arousal, fear-like and aversive processes in Wistar rats. The profile of global efficacy for the centrally administered CRF receptor agonist was characterized by low dose (0.5-1.0 mug) arousal-like effectsin locomotor and conditioned ambulation contexts and by high dose (5-25 mug) conditioned immobility, taste aversion and place aversion. In contrast, a profile of limited efficacy for the centrally administered CRF binding protein ligand inhibitor included only dose dependent motor activating and facilitation of fear conditioning effects without any of the anxiogenic-like or aversive properties of CRF agonist administration. These results suggestthat arousal-like activation is a fundamental, physiologically relevant consequence of brain CRF system stimulation whereas aversive and anxiety-likeeffects reflect pharmacological actions of a CRF receptor agonist. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/05/20 alle ore 23:04:15