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Titolo:
Estradiol alleviates depressive-like symptoms in a novel animal model of post-partum depression
Autore:
Galea, LAN; Wide, JK; Barr, AM;
Indirizzi:
Univ British Columbia, Dept Psychol, Vancouver, BC V6T 1Z4, Canada Univ British Columbia Vancouver BC Canada V6T 1Z4 ver, BC V6T 1Z4, Canada Univ British Columbia, Neurosci Program, Vancouver, BC V6T 1Z4, Canada Univ British Columbia Vancouver BC Canada V6T 1Z4 ver, BC V6T 1Z4, Canada
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1, volume: 122, anno: 2001,
pagine: 1 - 9
SICI:
0166-4328(200107)122:1<1:EADSIA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
FORCED SWIMMING TEST; SEVERE POSTNATAL DEPRESSION; POSTPARTUM MOOD DISORDERS; ANXIETY-RELATED BEHAVIOR; RECEPTOR MESSENGER-RNA; SENSITIVE LINE RATS; MATERNAL-BEHAVIOR; ESTROUS-CYCLE; TRANSDERMAL ESTROGEN; CHILD-DEVELOPMENT;
Keywords:
estradiol; progesterone; pregnancy; post-partum depression; forced-swim test; mood;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Galea, LAN Univ British Columbia, Dept Psychol, 2136 W Mall, Vancouver, BCV6T 1Z4, Canada Univ British Columbia 2136 W Mall Vancouver BC Canada V6T 1Z4 a
Citazione:
L.A.N. Galea et al., "Estradiol alleviates depressive-like symptoms in a novel animal model of post-partum depression", BEH BRA RES, 122(1), 2001, pp. 1-9

Abstract

The effect of hormone withdrawal following hormone-simulated "pregnancy" on "depressive-like behavior" in the Forced Swim Test (FST) was investigatedin female Long-Evans rats. Females were randomly assigned to "pregnant", "pregnant" + estradiol benzoate (EB), and control groups. Both the "pregnant" and "pregnant" + EB groups received daily injections of the hormones estradiol and progesterone to simulate the 23-day gestational period in the rat. However, the "pregnant" + EB group continued to receive daily estradiol injections after "pregnancy". All groups were tested 48 h after the last injection of the pregnancy period in the FST and subsequently in the Open Field Test (OFT). Results revealed that the "pregnant" rats exhibited significantly increased immobility and decreased struggling and swimming behaviors as compared to the "pregnant" + EB and control groups. These findings could not be explained by an overall depression in general locomotor activity among "pregnant" rats, as the "pregnant" rats made more area crossings in the OFT. Thus "pregnant" rats exhibited behaviors consistent with "depressive-like" symptoms "post-partum" (after their hormone regime was discontinued). Continual treatment with high levels of estradiol in the "pregnant" + EB group, however, reversed the exhibition of these behaviors. These results imply that withdrawal from chronic high levels of pregnancy-associated hormones (estradiol and progesterone) can produce depressed symptomology in rodents, which can be prevented by prolonging exposure to high levels of estradiol through the post-partum period. These findings are the first demonstration of "depressive-like" symptoms in a rodent model of post-partum pregnancy and the ability of high levels of estradiol to attenuate these ''depressive-like" symptoms. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:19:45