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Titolo:
Adrenomedullin inhibits angiotensin II-induced expression of tissue factorand plasminogen activator inhibitor-1 in cultured rat aortic endothelial cells
Autore:
Sugano, T; Tsuji, H; Masuda, H; Nishimura, H; Yoshizumi, M; Kawano, H; Kimura, S; Ukimura, N; Yano, S; Kunieda, Y; Nakagawa, K; Nakagawa, M;
Indirizzi:
Kyoto Prefectural Univ Med, Dept Med 2, Kamigyo Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 Ku, Kyoto 6028566, Japan
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 6, volume: 21, anno: 2001,
pagine: 1078 - 1083
SICI:
1079-5642(200106)21:6<1078:AIAIEO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; PROADRENOMEDULLIN N-TERMINAL-20 PEPTIDE; INCREASED PLASMA ADRENOMEDULLIN; MODIFYING PROTEINS RAMPS; NITRIC-OXIDE; NATRIURETIC PEPTIDES; INDUCED VASODILATION; HYPOTENSIVE PEPTIDE; MESANGIAL CELLS; RECEPTORS;
Keywords:
adrenomedullin; angiotensin II; plasminogen activator inhibitor-1; tissue factor; vascular endothelial cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Tsuji, H Kyoto Prefectural Univ Med, Dept Med 2, Kamigyo Ku, 465 Kawaramachi Hirokoji, Kyoto 6028566, Japan Kyoto Prefectural Univ Med 465 Kawaramachi Hirokoji Kyoto Japan 6028566
Citazione:
T. Sugano et al., "Adrenomedullin inhibits angiotensin II-induced expression of tissue factorand plasminogen activator inhibitor-1 in cultured rat aortic endothelial cells", ART THROM V, 21(6), 2001, pp. 1078-1083

Abstract

Adrenomedullin (AM) is a potent vasodilating peptide having a variety of pharmacological properties mainly in respect to vascular pathophysiology. Wehave previously demonstrated that angiotensin II (Ang II) or natriuretic peptides have influence on the expression of tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) in vascular endothelial cells. The aim ofthis study was to elucidate the effects of AM on TF and PAI-1 mRNA and protein expression in endothelial cells. As a result, AM inhibited Ang II-induced TF and PAI-1 mRNA expression in a dose-and time-dependent manner. Because the expression of TF and PAI-1 mRNA induced by Ang II was attenuated by the increase of intracellular concentrations of cAMP by forskolin and 8-bromo-cAMP and because AM increased the intracellular level of cAMP in rat aortic endothelial cells, it was indicated that the inhibitory effect of AM onthe expressions of TF and PAI-1 was mainly mediated by the cAMP-dependent signal transduction. Furthermore, the inhibitory effect of AM on TF and PAI-1 expression was partly attenuated by an NO synthase inhibitor, NG-nitro-L-arginine methyl ester. Tn conclusion, AM is shown to contribute to the regulation of blood coagulation and fibrinolysis by vascular endothelial cellsmainly via the cAMP pathway.

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Documento generato il 15/07/20 alle ore 07:39:09