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Titolo:
Pro-oxidant effect of vitamin E in cigarette smokers consuming a high polyunsaturated fat diet
Autore:
Weinberg, RB; VanderWerken, BS; Anderson, RA; Stegner, JE; Thomas, MJ;
Indirizzi:
Wake Forest Univ, Sch Med, Dept Internal Med, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA Wake Forest Univ, Sch Med, Gen Clin Res Ctr, Gastroenterol Sect, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA Wake Forest Univ, Sch Med, Dept Biochem, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 6, volume: 21, anno: 2001,
pagine: 1029 - 1033
SICI:
1079-5642(200106)21:6<1029:PEOVEI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; TOCOPHEROL-MEDIATED PEROXIDATION; INCREASED LIPID-PEROXIDATION; ALPHA-TOCOPHEROL; E SUPPLEMENTATION; BETA-CAROTENE; OXIDATIVE MODIFICATION; CARDIOVASCULAR-DISEASE; ANTIOXIDANT VITAMINS; PLASMA-LIPOPROTEINS;
Keywords:
LDL; lipid oxidation; antioxidants; alpha-tocopherol; F-2-isoprostanes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Weinberg, RB Wake Forest Univ, Sch Med, Dept Internal Med, Med Ctr Blvd, Winston Salem,NC 27157 USA Wake Forest Univ Med Ctr Blvd Winston Salem NC USA 27157 USA
Citazione:
R.B. Weinberg et al., "Pro-oxidant effect of vitamin E in cigarette smokers consuming a high polyunsaturated fat diet", ART THROM V, 21(6), 2001, pp. 1029-1033

Abstract

Dietary polyunsaturated fats and vitamin E are associated with reduced risk for atherosclerosis, but in smokers, they could promote lipid oxidation. Therefore, we examined the effects of a high polyunsaturated fat diet and vitamin E supplementation on measures of lipid oxidation in cigarette smokers. Ten subjects who smoked >1 pack of cigarettes per day were sequentially fed the following: a baseline diet in which the major fat source was olive oil, a diet in which the major fat source was high-linoleic safflower oil, and finally, the safflower oil diet plus 800 IU vitamin E per day. LDL oxidation lag time and rate and plasma total F-2-isoprostanes and prostaglandinF-2 alpha (PGF(2 alpha)) were determined after 3 weeks on each diet. The safflower oil diet increased total F-2-isoprostanes from 53.0 +/-7.2 to 116.2 +/- 11.2 nmol/L and PGF(2 alpha) from 3.5 +/-0.2 to 5.5 +/-0.5 nmol/L, without changing LDL oxidation parameters. Addition of vitamin E prolonged mean LDL oxidation lag time but, paradoxically, further increased F-2-isoprostanes to 188.2 +/- 10.9 nmol/L and PGF(2 alpha) to 7.8 +/-0.4 nmol/L. Thesedata suggest that vitamin E may function as a pro-oxidant in cigarette smokers consuming a high polyunsaturated fat diet.

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Documento generato il 04/06/20 alle ore 00:43:26