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Titolo:
Effect of immune deficiency on lipoproteins and atherosclerosis in male apolipoprotein E-deficient mice
Autore:
Reardon, CA; Blachowicz, L; White, T; Cabana, V; Wang, YG; Lukens, J; Bluestone, J; Getz, GS;
Indirizzi:
Univ Chicago, Dept Pathol, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 ago, Dept Pathol, Chicago, IL 60637 USA
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 6, volume: 21, anno: 2001,
pagine: 1011 - 1016
SICI:
1079-5642(200106)21:6<1011:EOIDOL>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
E KNOCKOUT MICE; APO-E; REDUCES ATHEROSCLEROSIS; ATHEROGENIC DIET; HIGH TITERS; /-MICE; LESIONS; LYMPHOCYTE; INDUCTION; CYTOKINES;
Keywords:
atherosclerosis; apolipoprotein E; immune deficiency; T cells; lipoproteins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Reardon, CA Univ Chicago, Dept Pathol, MC 1089,5841 S Maryland Ave, Chicago, IL 60637 USA Univ Chicago MC 1089,5841 S Maryland Ave Chicago IL USA 60637
Citazione:
C.A. Reardon et al., "Effect of immune deficiency on lipoproteins and atherosclerosis in male apolipoprotein E-deficient mice", ART THROM V, 21(6), 2001, pp. 1011-1016

Abstract

To determine whether T cells and B cells influence lipid metabolism and atherosclerosis, we crossed apolipoprotein E-deficient (apoE degrees) mice with recombination activating gene 2-deficient (RAG2 degrees) mice. Total plasma cholesterol levels were approximate to 20% higher in male apoE degrees mice compared with the apoE degrees RAG2 degrees mice at 8 weeks of age, and plasma triglyceride levels were 2.5-fold higher in the apoE degrees mice even when plasma cholesterol levels were similar. Male mice with plasma cholesterol levels between 400 and 600 mg/dL at 8 weeks of age were euthanizedat 27 and 40 weeks of age. The aortic root lesion area in the apoE"RAG2" mice, compared with that in the immune-competent apoE degrees mice, was 81% and 57% smaller at 27 and 40 weeks of age, respectively. In contrast, therewas no difference in the size of the brachiocephalic trunk lesions. Similar results were obtained with mice euthanized at 40 weeks of age that had 8-week cholesterol levels between 300 and 399 mg/dL. In apoE"RAG2" mice, aortic root atherosclerosis was more profoundly suppressed at lower cholesterollevels. Thus, T and B cells and their products differentially influence the development of atherosclerosis at different sites. We also demonstrate a profound effect of the immune system on plasma lipid homeostasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:12:26