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Titolo:
High-fat, high-cholesterol diet increases the incidence of gastritis in LDL receptor-negative mice
Autore:
Laurila, A; Cole, SP; Merat, S; Obonyo, M; Palinski, W; Fierer, J; Witztum, JL;
Indirizzi:
Univ Calif San Diego, Div Endocrinol & Metab, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 Metab, La Jolla, CA 92093 USA Univ Calif San Diego, Div Infect Dis, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 ct Dis, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 pt Med, La Jolla, CA 92093 USA VA Healthcare San Diego, La Jolla, CA USA VA Healthcare San Diego La Jolla CA USA care San Diego, La Jolla, CA USA
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 6, volume: 21, anno: 2001,
pagine: 991 - 996
SICI:
1079-5642(200106)21:6<991:HHDITI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; FACTOR-KAPPA-B; APOE-DEFICIENT MICE; HELICOBACTER-PYLORI; APOLIPOPROTEIN-E; OXIDIZED LDL; ATHEROSCLEROSIS; LESIONS; HYPERCHOLESTEROLEMIA; EPITOPES;
Keywords:
inflammation; atherosclerosis; gastritis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Witztum, JL Univ Calif San Diego, Div Endocrinol & Metab, 1080 Basic Sci Bldg,9500 Gilman Dr, La Jolla, CA 92093 USA Univ Calif San Diego 1080 Basic Sci Bldg,9500 Gilman Dr La Jolla CA USA 92093
Citazione:
A. Laurila et al., "High-fat, high-cholesterol diet increases the incidence of gastritis in LDL receptor-negative mice", ART THROM V, 21(6), 2001, pp. 991-996

Abstract

Transgenic and knockout mice are widely used as models for atherogenesis studies. While developing a Helicobacter infection model in LDL receptor-negative (LDLR-/-) mice, we noticed that mice fed a high-fat, high-cholesteroldiet often contracted gastritis independent of infection. To further investigate this finding, we studied 27 male and 18 female LDLR-/- mice fed high-fat. 1% or 1.25% cholesterol diets for 3 to 4 months. The extent of atherosclerosis was morphometrically analyzed in the whole aorta, and the degree of gastric inflammation was scored histologically in hematoxylin-eos in-stained stomach sections. The autoantibody titers to epitopes of oxidized LDL were also measured. Mice fed high-fat, high-cholesterol diets had a significantly higher incidence of gastritis than mice fed normal chow, 62% versus 5%, respectively (P <0.0001). This effect was specific for LDLR-/- mice, because no difference in gastritis was found in wild-type mice fed either diet. Animals with gastritis showed slightly more atherosclerosis than animalswithout gastritis: 16.3 +/-6.4% versus 12.8 +/-3.4% in males and 9.1 +/-3.5% versus 6.5 +/-3.3% in females. Cholesterol-fed mice also had significantly higher IgG autoantibody titers against modified LDL than normal chow-fedanimals, but no difference was seen between the gastritis and nongastritisgroups. We conclude that the standard high-fat, high-cholesterol diet commonly used in many murine models to induce atherosclerosis increased the incidence of gastritis significantly in LDLR-/- mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 06:54:40