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Titolo:
2000 George Lyman Duff Memorial Lecture - Atherosclerosis is a liver disease of the heart
Autore:
Davis, RA; Hui, TY;
Indirizzi:
San Diego State Univ, Mammalian Cell & Mol Biol Lab, San Diego, CA 92182 USA San Diego State Univ San Diego CA USA 92182 Lab, San Diego, CA 92182 USA
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 6, volume: 21, anno: 2001,
pagine: 887 - 898
SICI:
1079-5642(200106)21:6<887:2GLDML>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRIGLYCERIDE TRANSFER PROTEIN; LOW-DENSITY-LIPOPROTEIN; STEROL REGULATORY ELEMENT; B-CONTAINING LIPOPROTEINS; HUMAN APOLIPOPROTEIN-B; ENDOPLASMIC-RETICULUM MEMBRANE; CHOLESTEROL 7-ALPHA-HYDROXYLASE CYP7A; UBIQUITIN-PROTEASOME PATHWAY; POLYUNSATURATED FATTY-ACIDS; STEAROYL-COA DESATURASE-1;
Keywords:
apolipoprotein B; lipoprotein assembly/secretion; cholesterol-7 alpha-hydroxylase; microsomal triglyceride transfer protein ubiquitin-dependent proteasome degradation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
175
Recensione:
Indirizzi per estratti:
Indirizzo: Davis, RA San Diego State Univ, Mammalian Cell & Mol Biol Lab, Life Sci Bldg LS307,5500 Campanile Dr, San Diego, CA 92182 USA San Diego State Univ Life Sci Bldg LS307,5500 Campanile Dr San Diego CA USA 92182
Citazione:
R.A. Davis e T.Y. Hui, "2000 George Lyman Duff Memorial Lecture - Atherosclerosis is a liver disease of the heart", ART THROM V, 21(6), 2001, pp. 887-898

Abstract

The production of apolipoprotein B (apoB)-containing lipoproteins by the liver is regulated by a complex series of processes involving apoB being cotranslationally translocated across the endoplasmic reticulum and assembled into a lipoprotein particle. The translocation of apoB across the endoplasmic reticulum is facilitated by the intraluminal chaperone, microsomal triglyceride transfer protein (MTP). MTP facilitates the translocation and folding of apoB, as well as the addition of lipid to lipid-binding domains (which consist of amphipathic beta sheets and alpha helices). In the absence of MTP or sufficient lipid, apoB exhibits translocation arrest. Thus, apoB translation, translocation, and assembly with lipids to form a core-containinglipoprotein particle occur as concerted processes. Abrogation of greater than or equal to1 of these processes diverts apoB into a degradation pathwaythat is dependent on conjugation with ubiquitin and proteolysis by the proteasome. The nascent core-containing lipoprotein particle that forms withinthe lumen of the endoplasmic reticulum can be "enlarged" to form a mature very low density lipoprotein particle. Additional studies show that the assembly and secretion of apoB-containing lipoproteins are linked to the cholesterol/bile acid synthetic pathway controlled by cholesterol 7 alpha -hydroxylase. Studies in cultured cells and transgenic mice indicate that the expression of cholesterol 7 alpha -hydroxylase indirectly regulates the expression of lipogenic enzymes through changes in the cellular content of maturesterol response element binding proteins. Oxysterols and bile acids may also act via the ligand-activated nuclear receptors LXR and FXR to link the metabolic pathways controlling energy balance and lipid metabolism to nutritional state.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 07:40:30