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Titolo:
An alternatively spliced Muc10 glycoprotein ligand for putative L-selectinbinding during mouse embryonic submandibular gland morphogenesis
Autore:
Melnick, M; Chen, HM; Zhou, YM; Jaskoll, T;
Indirizzi:
Univ So Calif, Lab Dev Genet, Los Angeles, CA 90089 USA Univ So Calif LosAngeles CA USA 90089 v Genet, Los Angeles, CA 90089 USA
Titolo Testata:
ARCHIVES OF ORAL BIOLOGY
fascicolo: 8, volume: 46, anno: 2001,
pagine: 745 - 757
SICI:
0003-9969(200108)46:8<745:AASMGL>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
WISKOTT-ALDRICH SYNDROME; WEIGHT SALIVARY MUCIN; CELL-ADHESION; GLYCOSYLATION SITES; PROTEIN SEQUENCES; EPITHELIAL MUCIN; O-GLYCOSYLATION; MESSENGER-RNA; TGF-BETA; PREDICTION;
Keywords:
submandibular salivary gland; embryo; mouse; mucin sequence; L-selectin binding;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Melnick, M Univ So Calif, Lab Dev Genet, 925 W 34th St,DEN-4266, Los Angeles, CA 90089 USA Univ So Calif 925 W 34th St,DEN-4266 Los Angeles CA USA 90089 A
Citazione:
M. Melnick et al., "An alternatively spliced Muc10 glycoprotein ligand for putative L-selectinbinding during mouse embryonic submandibular gland morphogenesis", ARCH ORAL B, 46(8), 2001, pp. 745-757

Abstract

Late-gestation (embryonic day 18; E18) mouse submandibular glands (SMG) comprise a network of large and small ducts that terminate in lumen-containing, presumptive acini (terminal buds) expressing unique, cell membrane-associated embryonic mucin. The objective here was to clone and sequence embryonic low molecular-weight SMG mucin, predict its secondary structure, and begin to investigate its possible role in SMG development. Evidence was found that: (1) embryonic low molecular-weight mucin is an alternatively spliced Muc10 gene product, 220 amino acids in size (approximately 25 kDa), rich inpotential O-glycosylation sites, and variably glycosylated (approximately 40 and 65 kDa); (2) consensus secondary-structure prediction for embryonic low molecular-weight mucin is consistent with a molecule that is anchored to the plasma membrane, directly or indirectly (via a glycolipid), and has aprotein core that serves as a scaffold for carbohydrate presentation; (3) embryonic L-selectin is immunolocalized to the plasma membrane region of terminal-bud epithelial cells in a pattern similar to that seen for embryonicmucin; (4) embryonic, but not adult, mucin is able to bind L-selectin and does so endogenously in E18 SMG. As the primary role of L-selectin is to mediate cell adhesion and its ligands are mucin-like glycoproteins, it is suggested that this embryonic low molecular-weight mucin be termed MucCAM. (C)2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 06:06:36