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Titolo:
Detection of IgA autoantibodies to desmogleins by an enzyme-linked immunosorbent assay - The presence of new minor subtypes of IgA pemphigus
Autore:
Hashimoto, T; Komai, A; Futei, Y; Nishikawa, T; Amagai, M;
Indirizzi:
Kurume Univ, Sch Med, Dept Dermatol, Fukuoka 8300011, Japan Kurume Univ Fukuoka Japan 8300011 Dept Dermatol, Fukuoka 8300011, Japan Keio Univ, Sch Med, Dept Dermatol, Tokyo, Japan Keio Univ Tokyo JapanKeio Univ, Sch Med, Dept Dermatol, Tokyo, Japan
Titolo Testata:
ARCHIVES OF DERMATOLOGY
fascicolo: 6, volume: 137, anno: 2001,
pagine: 735 - 738
SICI:
0003-987X(200106)137:6<735:DOIATD>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBCORNEAL PUSTULAR DERMATOSIS; VESICULOPUSTULAR DERMATOSIS; PATHOGENIC AUTOANTIBODIES; VULGARIS ANTIGEN; FOLIACEUS; AUTOANTIGENS; BACULOVIRUS; ANTIBODIES; CADHERINS; ADHESION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Hashimoto, T Kurume Univ, Sch Med, Dept Dermatol, 67 Asahimachi, Fukuoka 8300011, Japan Kurume Univ 67 Asahimachi Fukuoka Japan 8300011 00011, Japan
Citazione:
T. Hashimoto et al., "Detection of IgA autoantibodies to desmogleins by an enzyme-linked immunosorbent assay - The presence of new minor subtypes of IgA pemphigus", ARCH DERMAT, 137(6), 2001, pp. 735-738

Abstract

Objective: To examine the frequency of antidesmoglein 1 (Dsg1) and antidesmoglein 3 (Dsg3) IgA autoantibodies in IgA pemphigus. Design: We developed an enzyme-linked immunosorbent assay against recombinant Dsg1 and Dsg3 to detect IgA autoantibodies. Patients: Twenty-two patients with IgA pemphigus were studied. Among them,10 patients had subcorneal pustular dermatosis type, 9 patients had intraepidermal neutrophilic IgA dermatosis type, and 3 patients had pemphigus foliaceus-like clinical features. Results: Of the 22 cases of IgA pemphigus, 3 cases were positive for anti-Dsg1 IgA antibodies and only 1 case was positive for anti-Dsg3 IgA antibodies. In those 4 cases, there were no IgA autoantibodies against other components of the keratinocyte cell surfaces because preincubation with the respective recombinant desmogleins removed the immunoreactivity on immunofluorescence. All 10 patients with subcorneal pustular dermatosis type IgA pemphigus were positive against desmocollin 1 expressed on COS-7 cells. No target antigen was detected in the other 8 cases. Conclusions: Desmogleins were recognized by IgA antibodies of a few patients with IgA pemphigus. Considering that subcorneal pustular dermatosis typeIgA pemphigus recognizes desmocollin I, autoimmune targets of IgA pemphigus are more heterogeneous than previously considered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:29:35