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Titolo:
Vascular delay and intermittent stimulation: Keys to successful latissimusdorsi muscle stimulation
Autore:
Kashem, A; Santamore, WP; Chiang, B; Unger, L; Ali, AT; Slater, AD;
Indirizzi:
Temple Univ, Sch Med, Div Cardiovasc Res, Cardiol Sect, Philadelphia, PA 19140 USA Temple Univ Philadelphia PA USA 19140 ol Sect, Philadelphia, PA 19140 USA Univ Louisville, Dept Surg, Div Cardiothorac Surg, Louisville, KY 40292 USA Univ Louisville Louisville KY USA 40292 ac Surg, Louisville, KY 40292 USA
Titolo Testata:
ANNALS OF THORACIC SURGERY
fascicolo: 6, volume: 71, anno: 2001,
pagine: 1866 - 1873
SICI:
0003-4975(200106)71:6<1866:VDAISK>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR FUNCTION; DYNAMIC CARDIOMYOPLASTY; SKELETAL-MUSCLE; BLOOD-FLOW; DIASTOLIC FUNCTION; FOLLOW-UP; RABBIT; SHEEP; POWER; HEART;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Kashem, A Temple Univ, Sch Med, Div Cardiovasc Res, Cardiol Sect, Med Res Bldg,Room 800A,3420 N Broad St, Philadelphia, PA 19140 USA Temple Univ Med Res Bldg,Room 800A,3420 N Broad St Philadelphia PA USA 19140
Citazione:
A. Kashem et al., "Vascular delay and intermittent stimulation: Keys to successful latissimusdorsi muscle stimulation", ANN THORAC, 71(6), 2001, pp. 1866-1873

Abstract

Background. The goal of this study was to obtain physiologically significant increases in peak left ventricular (LV) systolic pressure and stroke volume with latissimus dorsi muscle (LDM) stimulation in cardiomyoplasty (CMP). We hypothesized that preserving LDM integrity by vascular delay and intermittent stimulation would significantly increase LDM cardiac assistance. Methods. In 4 control dogs and 12 dogs that had undergone a vascular delay(VD) procedure, LV dysfunction was induced by intracoronary microsphere injections. Cardiomyoplasty surgery was performed 14 days later, followed by progressive LDM conditioning. In the control dogs and in 6 of the VD dogs, the LDM was stimulated 24 hours per day (VD plus constant stimulation [CS]). In the other 6 VD dogs, LDMs were stimulated on a daily schedule of 10 hours on and 14 hours off (VD plus interrupted stimulation [IS]). Latissimus dorsi muscle stimulated beats were compared with nonstimulated beats 9 weeks later. Results. In the control dogs, LDM stimulation had minimal effects. In VD CS and VD + IS, LD M stimulation increased peak LV pressure, stroke volume, stroke work, and stroke power (p < 0.05). However, these changes were greater in the VD + IS group, in which LDM stimulation increased peak aortic pressure by 17.6 +/- 1.7 mm Hg, peak LV pressure by 19.7 +/- 1.1 mm Hg, peakpositive LV dp/dt by 398 +/- 144 mm Hg per second, stroke volume by 5.1 +/- 0.7 mt, stroke work by 10.9 +/- 0.9 gm m, and stroke power by 122.7 +/- 11.6 gm m per second (p < 0.05 compared with VD + CS). Quantitative morphometric analysis showed minimal LDM degeneration in the VD + IS group (7.5% +/- 1.1%), and VD + CS group (10.5% +/- 4.5%) compared with the control group(29.5% +/- 4.5%, p < 0.05). Conclusions. VD and IS considerably increased the LV assistance with LDM stimulation. Further studies of this combined approach to CMP should be planned.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 12:09:37