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Titolo:
Mediterranean and low-fat diets improve endothelial function in hypercholesterolemic men
Autore:
Fuentes, F; Lopez-Miranda, J; Sanchez, E; Sanchez, F; Paez, J; Paz-Rojas, E; Marin, C; Gomez, P; Jimenez-Pereperez, J; Ordovas, JM; Perez-Jimenez, F;
Indirizzi:
Hosp Univ Reina Sofia, Unidad Lipidos & Arteriosclerosis, Cordoba 14004, Spain Hosp Univ Reina Sofia Cordoba Spain 14004 clerosis, Cordoba 14004, Spain Tufts Univ, Jean Meyer US Dept Agr Human Nutr Res Ctr Aging, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 n Nutr Res Ctr Aging, Boston, MA 02111 USA
Titolo Testata:
ANNALS OF INTERNAL MEDICINE
fascicolo: 12, volume: 134, anno: 2001,
pagine: 1115 - 1119
SICI:
0003-4819(20010619)134:12<1115:MALDIE>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO; ATHEROSCLEROSIS; DYSFUNCTION; FOREARM; RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Perez-Jimenez, F Hosp Univ Reina Sofia, Unidad Lipidos & Arteriosclerosis,Avda Menendez Pidal S-N, Cordoba 14004, Spain Hosp Univ Reina Sofia Avda Menendez Pidal S-N Cordoba Spain 14004
Citazione:
F. Fuentes et al., "Mediterranean and low-fat diets improve endothelial function in hypercholesterolemic men", ANN INT MED, 134(12), 2001, pp. 1115-1119

Abstract

Background: The regulatory function of the endothelium is altered in hypercholesterolemia, and the subsequent endothelial dysfunction plays a centralrole in the development of atherosclerosis. Objective: To determine whether endothelial function in hypercholesterolemic patients is affected by replacing a saturated fat-enriched diet with a low-fat, low-saturated fat diet (the U,S, National Cholesterol Education Program stage 1 [NCEP-1] diet) or a diet rich in monounsaturated fat (such as that common in Mediterranean countries). Design: Intervention dietary study with a baseline phase and two randomized crossover dietary periods. Setting: Hospital Universitario Reina Sofia, Cordoba, Spain,Patients: 22 hypercholesterolemic men. Intervention: Patients followed a diet high in saturated fat, then were assigned in a crossover design to the NCEP-1 diet or a Mediterranean diet. Each dietary period lasted 28 days. Measurements: Plasma P-seledin levels, lipid concentrations, and endothelial function,Results: Compared with the saturated fat diet, flow-mediated dilatation increased during the Mediterranean diet but not during the NCEP-1 diet In addition, levels of plasma cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, and P-selectin decreased during the NCEP-1 and Mediterranean diets. Conclusion: In hypercholesterolemic men, diets low in fat (especially saturated fat) and diets rich in monounsaturated fats improve endothelial function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:38:53