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Titolo:
Pharmacological elevation of endogenous kynurenic acid levels activates nigral dopamine neurons
Autore:
Erhardt, S; Oberg, H; Mathe, JM; Engberg, G;
Indirizzi:
Karolinska Inst, Dept Physiol & Pharmacol, SE-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17177 ol, SE-17177 Stockholm, Sweden
Titolo Testata:
AMINO ACIDS
fascicolo: 4, volume: 20, anno: 2001,
pagine: 353 - 362
SICI:
0939-4451(2001)20:4<353:PEOEKA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SUBSTANTIA-NIGRA; FIRING PATTERN; DIZOCILPINE MK-801; NUCLEUS-ACCUMBENS; BRAIN; INVIVO; IDENTIFICATION; INCREASE; CORTEX;
Keywords:
amino acids; kynurenic acid; firing rate; burst activity; PNU 156561A; substantia nigra; dopamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Engberg, G Karolinska Inst, Dept Physiol & Pharmacol, SE-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17177 7 Stockholm, Sweden
Citazione:
S. Erhardt et al., "Pharmacological elevation of endogenous kynurenic acid levels activates nigral dopamine neurons", AMINO ACIDS, 20(4), 2001, pp. 353-362

Abstract

Inhibitors of kynurenine 3-hydroxylase have previously been used to increase endogenous levels of kynurenic acid, an excitatory amino acid receptor antagonist. In the present electrophysiological study PNU 156561A was utilized to elevate endogenous concentrations of kynurenic acid and subsequent effects on the firing pattern of dopamine (DA) neurons of rat substantia nigra (SN) were analyzed. Pretreatment with PNU 156561A (40 mg/kg, i.v., 5-7 h)caused a five-fold increase in endogenous kynurenic acid levels in whole brain five to seven hours after administration and also evoked a significantincrease in firing rate and bursting activity of nigral DA neurons. The results of the present study show that a moderate increase in endogenous kynurenic acid levels produces significant actions on the tonic glutamatergic control of the firing pattern of nigral DA neurons, and implicate kynurenine3-hydroxylase inhibitors as novel antiparkinsonian agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 06:57:58