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Titolo:
Distal lung dysfunction at night in nocturnal asthma
Autore:
Kraft, M; Pak, J; Martin, RJ; Kaminsky, D; Irvin, CG;
Indirizzi:
Univ Colorado, Hlth Sci Ctr, Natl Jewish Med & Res Ctr, Div Pulm Sci & Crit Care Med, Denver, CO 80206 USA Univ Colorado Denver CO USA 80206 i & Crit Care Med, Denver, CO 80206 USA Univ Vermont, Coll Med, Div Pulm Dis & Crit Care Med, Burlington, VT USA Univ Vermont Burlington VT USA m Dis & Crit Care Med, Burlington, VT USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 7, volume: 163, anno: 2001,
pagine: 1551 - 1556
SICI:
1073-449X(200106)163:7<1551:DLDANI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMALL AIRWAYS; COLLATERAL VENTILATION; PULMONARY SURFACTANT; PERIPHERAL AIRWAYS; ALVEOLAR TISSUE; DRY AIR; INFLAMMATION; PARENCHYMA; STIMULATION; DIMENSIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Kraft, M Univ Colorado, Hlth Sci Ctr, Natl Jewish Med & Res Ctr, Div Pulm Sci & Crit Care Med, 1400 Jackson St,J107, Denver, CO 80206 USA Univ Colorado 1400 Jackson St,J107 Denver CO USA 80206 80206 USA
Citazione:
M. Kraft et al., "Distal lung dysfunction at night in nocturnal asthma", AM J R CRIT, 163(7), 2001, pp. 1551-1556

Abstract

We have previously shown that patients with nocturnal worsening of asthma (nocturnal asthma) exhibit increased parenchymal inflammation at night. To evaluate the functional significance of this parenchymal inflammation, 10 subjects with nocturnal asthma (NA), four subjects with non-nocturnal asthma(NNA), and four normal control subjects underwent bronchoscopy with measurement of peripheral airways resistance (Rp) at 4:00 P.M. and at 4:00 A.M. Employing a wedged bronchoscope technique, Rp was measured. Flow was stopped, and the pressure reached after 10 s of decay was termed the plateau pressure. The time constant of this decay (tau) was measured, and the peripheralcompliance (Cp) was calculated as tau /Rp. The NA group exhibited the highest Rp values at 4:00 P.M. and at 4:00 A.M. as compared with the NNA and control groups, but all groups were significantly different from each other at 4:00 P.M.: NA, 0.113 +/- 0.02 cm H2O/ml/min; NNA, 0.033 +/- 0.005 cm H2O/ml/min; Control subjects, 0.010 +/- 0.001 cm H2O/ ml/min; p = 0.0001; and at 4:00 A.M.: NA, 0.129 +/- 0.023 cm H2O/ ml/min; NNA, 0.035 +/- 0.007 cm H2O/ml/min; Control subjects, 0.009 +/- 0.002 cm H2O/ml/min; p = 0.0003. Noneof the groups exhibited statistically significant differences in Rp between 4:00 P.M. and 4:00 A.M.. The plateau pressure increased significantly from 4:00 P.M. to 4:00 A.M., but only in the NA group (7.7 +/- 0.9 cm H2O at 4:00 P.M. versus 16.9 +/- 4.6 cm H2O at 4:00 A.M.; p = 0.0004). CP was decreased in the NA group as compared with the NNA and control groups at both 4:00 P.M. (p = 0.0003) and 4:00 A.M. (p = 0.003). The Rp positively correlated with the residual volume at both 4:00 P.M. (r = 0.71, p = 0.004) and 4:00A.M. (r = 0.59, p = 0.03). We conclude that the distal lung units, specifically the collateral channels, and may be functionally altered at night in NA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:13:46