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Titolo:
Antifungal susceptibility testing and the correlation with clinical outcome in neonatal candidemia
Autore:
Huang, YC; Kao, HT; Lin, TY; Kuo, AJ;
Indirizzi:
Chang Gung Univ, Chang Gung Childrens Hosp, Div Pediat Infect Dis, Tao Yuan 333, Taiwan Chang Gung Univ Tao Yuan Taiwan 333 iat Infect Dis, Tao Yuan 333, Taiwan Chang Gung Mem Hosp, Dept Clin Pathol, Tao Yuan, Taiwan Chang Gung Mem Hosp Tao Yuan Taiwan Dept Clin Pathol, Tao Yuan, Taiwan
Titolo Testata:
AMERICAN JOURNAL OF PERINATOLOGY
fascicolo: 3, volume: 18, anno: 2001,
pagine: 141 - 146
SICI:
0735-1631(2001)18:3<141:ASTATC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE FUNGAL-INFECTIONS; INTENSIVE-CARE UNIT; AMPHOTERICIN-B; FLUCONAZOLE SUSCEPTIBILITY; CANDIDIASIS; MULTICENTER; THERAPY; TRIAL;
Keywords:
antifungal susceptibility test; neonate; candidemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Huang, YC Chang Gung Univ, Chang Gung Childrens Hosp, Div Pediat Infect Dis, 5 Fu Shin St,Kweishan, Tao Yuan 333, Taiwan Chang Gung Univ 5 Fu Shin St,Kweishan Tao Yuan Taiwan 333 aiwan
Citazione:
Y.C. Huang et al., "Antifungal susceptibility testing and the correlation with clinical outcome in neonatal candidemia", AM J PERIN, 18(3), 2001, pp. 141-146

Abstract

The objective of this article is to assess the distribution of minimal inhibition concentrations (MIC) for candidal isolates from, bloodstreams in neonates and to assess the correlation of clinical outcome with antifungal susceptibility testing. Of the 62 episodes of neonatal candidemia in a Children's Hospital between January 1994 and July 1998, 38 stocked isolates from 38 infants' bloodstreams were available and underwent antifungal susceptibility test according to National Committee for Clinical Laboratory StandardsM27-A document. Correlation of clinical response with in vitro results wasassessed in 37 patient-episode-isolate events. No less than 90% of these isolates test-ed were susceptible to amphotericin B, flucytosin, and fluconazole. The ranges of amphotericin B MICs and flucytosin MICs were narrow, ranging from 0.25 to 2 mug/mL, respectively. The range of fluconazole MICs was broad, ranging from 0.25 to > 64 mug/mL. Successful therapy was achieved in 18 (62%) of 29 amphotericin B-treated patient-episode-susceptible isolate (MIC less than or equal to1 mug/mL) events and 9 (64%) of 14 fluconazole-treated patient-episode-susceptible isolate events, respectively. Most isolates from the bloodstreams of neonates with candidemia were susceptible to antifungal agents tested but a low MIC of the antifungal agent did not predict successful therapy in this study. Correlating MICs with clinical outcome in neonatal candidemia requires complex evaluation of other factors.

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Documento generato il 04/07/20 alle ore 16:16:09