Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Insulin resistance precedes weight loss in adults without diabetes - The Rancho Bernardo study
Autore:
Wedick, NM; Mayer-Davis, EJ; Wingard, DL; Addy, CL; Barrett-Connor, E;
Indirizzi:
Univ Calif San Diego, Sch Med, Dept Family & Prevent Med, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 nt Med, La Jolla, CA 92093 USA Univ S Carolina, Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA Univ S Carolina Columbia SC USA 29208 l & Biostat, Columbia, SC 29208 USA
Titolo Testata:
AMERICAN JOURNAL OF EPIDEMIOLOGY
fascicolo: 12, volume: 153, anno: 2001,
pagine: 1199 - 1205
SICI:
0002-9262(20010615)153:12<1199:IRPWLI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR-DISEASE; HOMEOSTASIS MODEL; GLUCOSE-TOLERANCE; LOWER RATES; GAIN; OBESITY; HYPERINSULINEMIA; ATHEROSCLEROSIS; SENSITIVITY; WOMEN;
Keywords:
aging; body weight changes; cardiovascular diseases; diabetes mellitus; insulin resistance; obesity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Barrett-Connor, E Univ Calif San Diego, Sch Med, Dept Family & Prevent Med, 9500 Gilman Dr,349 Stein Clin Res Bldg, La Jolla, CA 92093 USA Univ CalifSan Diego 9500 Gilman Dr,349 Stein Clin Res Bldg La Jolla CA USA 92093
Citazione:
N.M. Wedick et al., "Insulin resistance precedes weight loss in adults without diabetes - The Rancho Bernardo study", AM J EPIDEM, 153(12), 2001, pp. 1199-1205

Abstract

Insulin resistance is closely associated with both aging and overweight; yet in old age, weight loss is common, although insulin resistance increases. To study this paradox, the authors evaluated the role of insulin resistance in weight change among older adults from the Rancho Bernardo Study cohort. Participants were 725 nondiabetic men and women who were aged 50-89 years when weight and insulin were measured at baseline (1984-1987). The participants were evaluated again in 1992-1996, at which time weight was remeasured. Pasting insulin and homeostasis model assessment (HOMA) measurements were evaluated in separate but parallel statistical models as surrogates for insulin resistance. Insulin resistance, when defined as the top quartile offasting insulin level or HOMA value, was significantly associated with weight loss before and after adjustment for baseline weight and age (fasting insulin: beta = -1.30 kg, p = 0.01; HOMA: beta = -1.18 kg, p = 0.01). Results were the same for men versus women, for the overweight (body mass index (weight (kg)/height (m)(2)) less than or equal to 26.6) versus the normal weight (body mass index > 26.6), and for younger persons (age < 70 years) versus older persons (age greater than or equal to 70 years). Insulin-resistant individuals had a threefold increased likelihood of losing 10 or more kg compared with those without insulin resistance. The authors conclude that hyperinsulinemia, independently of age and baseline weight, may have a catabolic effect in the elderly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:23:28