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Titolo:
Angiogenesis and apoptosis-related protein (p53, bcl-2, and bax) expression versus response of gastric adenocarcinomas to paclitaxel and carboplatin chemotherapy
Autore:
Giatromanolaki, A; Stathopoulos, GP; Koukourakis, MI; Rigatos, S; Vrettou, E; Kittas, C; Fountzilas, G; Sivridis, E;
Indirizzi:
Tumour & Angiogenesis Res Grp, Iraklion 71306, Crete, Greece Tumour & Angiogenesis Res Grp Iraklion Crete Greece 71306 , Crete, Greece Democritus Univ Thrace, Dept Pathol, Thrace, Greece Democritus Univ Thrace Thrace Greece hrace, Dept Pathol, Thrace, Greece Univ Athens, Ippocrat Hosp, Med Div 2, Athens, Greece Univ Athens AthensGreece ens, Ippocrat Hosp, Med Div 2, Athens, Greece Univ Thessalia, Dept Radiotherapy & Oncol, Thessalia, Greece Univ Thessalia Thessalia Greece Radiotherapy & Oncol, Thessalia, Greece Aristotelian Univ Salonika, Dept Pathol & Oncol, GR-54006 Salonika, GreeceAristotelian Univ Salonika Salonika Greece GR-54006 006 Salonika, Greece Univ Athens, Sch Med, Dept Histol, GR-11527 Athens, Greece Univ Athens Athens Greece GR-11527 Dept Histol, GR-11527 Athens, Greece
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
fascicolo: 3, volume: 24, anno: 2001,
pagine: 222 - 226
SICI:
0277-3732(200106)24:3<222:AAAP(B>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; PROGRAMMED CELL-DEATH; WILD-TYPE P53; TUMOR ANGIOGENESIS; CANCER CELLS; GENE BAX; RESISTANCE; PROGNOSIS; CARCINOMA; SURVIVAL;
Keywords:
gastric cancer; angiogenesis; p53bcl-2; bax; paclitaxel; carboplatin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Giatromanolaki, A Tumour & Angiogenesis Res Grp, 18 Dimokratias Ave, Iraklion 71306, Crete, Greece Tumour & Angiogenesis Res Grp 18 Dimokratias Ave Iraklion Crete Greece 71306
Citazione:
A. Giatromanolaki et al., "Angiogenesis and apoptosis-related protein (p53, bcl-2, and bax) expression versus response of gastric adenocarcinomas to paclitaxel and carboplatin chemotherapy", AM J CL ONC, 24(3), 2001, pp. 222-226

Abstract

The role of angiogenesis and apoptosis-related proteins in defining response to chemotherapy is poorly understood. We examined the microvessel density (MVD) and the expression of p53, bcl-2, and bax proteins in a series of 28 locally advanced gastric adenocarcinomas, treated with paclitaxel and carboplatin A strong cytoplasmic reactivity in mon than 10% of cancer cells was recorded in 25% of cases for p53 protein, and in 14% and 64% of cases forbcl-2 and bax proteins, respectively. Microvessel density was assigned in three categories: low (<35), medium (35-60), and high (>60). Tumors of medium MVD showed a significantly higher response rate compared with those of high or low MVD (p = 0.01 and 0.001, respectively), and prognosis was significantly better in this group of patients with medium MVD tumors (p< 0.02). Loss of bax protein expression was somewhat more frequent in tumors resistant to chemotherapy, but this difference was not of statistical significance. Nuclear p53 reactivity was associated with higher MVD (p = 0.02). The expression of p53 and bcl-2 did not influence the outcome of treatment. The present study suggests that although apoptosis-related proteins may have a role in defining response to taxanes, parameters related to tumors' vasculature, such as drug availability or angiogenic tissue regeneration, may be equally important.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 01:05:16