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Titolo:
Nasal IL-16 and MIP-1 alpha in late-phase allergic response
Autore:
Kramer, MF; Ostertag, P; Pfrogner, E; Rasp, G;
Indirizzi:
Univ Munich, Dept Otorhinolaryngol Head & Neck Surg, Munich, Germany Univ Munich Munich Germany nolaryngol Head & Neck Surg, Munich, Germany
Titolo Testata:
ALLERGY AND ASTHMA PROCEEDINGS
fascicolo: 3, volume: 22, anno: 2001,
pagine: 127 - 132
SICI:
1088-5412(200105/06)22:3<127:NIAMAI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTE CHEMOATTRACTANT FACTOR; BRONCHOALVEOLAR LAVAGE FLUID; EOSINOPHIL CATIONIC PROTEIN; MESSENGER-RNA; ANTIGEN CHALLENGE; GENE-EXPRESSION; T-CELLS; MUCOSA; CD4(+); INTERLEUKIN-16;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kramer, MF Klinikum Grosshadern, ENT Dept, Marchioninistr 15, D-81377 Munich, Germany Klinikum Grosshadern Marchioninistr 15 Munich Germany D-81377
Citazione:
M.F. Kramer et al., "Nasal IL-16 and MIP-1 alpha in late-phase allergic response", ALL ASTH P, 22(3), 2001, pp. 127-132

Abstract

Late-phase response in allergic rhinitis is characterized by tissue eosinophilia and influx of CD4(+) T-cells. IL-16 and MIP-la are highly chemotactic on T-cells and on eosinophils. Both IL-16 and MIP-1 alpha have been demonstrated to be up-regulated after challenge in the late-phase response in various atopic conditions other than allergic rhinitis. The aim of our study was to determine the expression of IL-16 and MIP-1 alpha in nasal secretions following allergen challenge in allergic rhinitis, and to compare these with characteristic late-phase mediators such as IL-5 and ECP. Nasal secretions of 14 allergic volunteers challenged intranasally by their specific allergen M ere studied from 20 minutes to 8 hours after allergen challenge. Nasal secretions were analyzed by routine ELISA for IL-16, MIP-1 alpha, IL-5,and ECP. IL-16 and MIP-1 alpha increased significantly in nasal secretionsof challenged allergic patients in the late-phase response. IL-16 revealedhighest amounts 5 hours after challenge, whereas MIP-1 alpha peaked at 7 hours. Both correlated significantly (r = 0.917 p < 0.05) at 6 hours. IL-5 and ECP peaked between 6 and 8 hours and correlated significantly (r = 0.951, p < 0.01) at 6 hours as well. Our data demonstrate that IL-16 and MIP-la are expressed in the late phase response in allergic rhinitis in a more or less similar kinetic like IL-5 and ECP. They are suggested to be responsible for the observed influx of eosinophils (IL-5, IL-16, and MIP-1 alpha) andCD4(+) T-cells (IL-16 and MIP-1 alpha) into the challenged allergic mucosa.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 14:51:11