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Titolo:
Diagnostic evaluation of grass- and birch-allergic patients with oral allergy syndrome
Autore:
Anhoj, C; Backer, V; Nolte, H;
Indirizzi:
Bispebjerg Univ Hosp, Dept Internal Med, Allergy & Asthma Unit, Copenhagen, Denmark Bispebjerg Univ Hosp Copenhagen Denmark sthma Unit, Copenhagen, Denmark
Titolo Testata:
ALLERGY
fascicolo: 6, volume: 56, anno: 2001,
pagine: 548 - 552
SICI:
0105-4538(200106)56:6<548:DEOGAB>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRESH FOODS; POLLEN; IGE; HYPERSENSITIVITY; SYMPTOMS; EXTRACTS;
Keywords:
apple; birch-pollen allergy; grass-pollen allergy; hazelnut; histamine release; melon; oral allergy syndrome; recombinant allergen; skin prick test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Nolte, H 35 Duntzfelts Alle, DK-2900 Hellerup, Denmark 35 Duntzfelts AlleHellerup Denmark DK-2900 0 Hellerup, Denmark
Citazione:
C. Anhoj et al., "Diagnostic evaluation of grass- and birch-allergic patients with oral allergy syndrome", ALLERGY, 56(6), 2001, pp. 548-552

Abstract

Background: Patients with birch and grass allergy often suffer from oral allergy symptoms when ingesting cross-reacting fresh fruits and vegetables. However, fruit and vegetable allergen extracts are often readily degradableor contain clinically irrelevant cross-reacting epitopes, resulting in diagnostic discrepancies when fruit and vegetable allergic reactions are evaluated. The risk of using nonstandardized fresh food extracts for skin testing may also be of concern. The objective was to compare and evaluate the clinical utility of selected recombinant grass and birch cross-reacting food allergens with fresh and commercial melon, hazelnut, and apple extracts. Methods: Thirty-six grass- and or birch-allergic patients and 17 control subjects consented to participate in the study. All subjects were skin pricktested and had basophil histamine-release tests done with fresh fruits andvarious extracts of hazelnut, apple, and melon. The diagnosis of oral allergy syndrome was confirmed by oral challenges. In addition, histamine release to recombinant Bet v 1 and Bet v 2, and recombinant Ph1 p 1 and Phl p 2,Phl p 5 was performed. Results: The skin prick test with fresh hazelnut, apple, and melon showed sensitivities of 0.97, 0.92, and 0.89, respectively. The corresponding specificities were 0.78, 0.72, and 0.82, respectively. In contrast, the histamine-release test with hazelnut, apple, and melon gave sensitivities of 0.87,0.71, and 1.00, respectively. The corresponding specificities were 0.65, 0.93, and 0.43. The skin prick test showed excellent negative predictive value (> 90%). No added value of recombinant allergen testing was noted. Oral challenge did not result in severe systemic reactions, and no systemic reactions were observed with skin prick tests with fresh fruits. Conclusions: The skin prick test showed an almost optimal diagnostic valuewith a satisfactory sensitivity (> 89%) and excellent negative predictive value with fresh fruits. When the skin prick test with fresh nut and apple cannot be performed, histamine release is a diagnostic alternative. Histamine release with melon showed lack of specificity. This was probably due to extensive IgE crossreactivity with pollen, since these patients also responded to recombinant Phl p 1 and Bet v 1. Skin testing and challenges with fresh fruits were safe.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:39:11