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Titolo:
Comparison of the effectiveness of non-nucleoside reverse transcriptase inhibitor-containing and protease inhibitor-containing regimens using observational databases
Autore:
Ghani, AC; Henley, WE; Donnelly, CA; Mayer, S; Anderson, RM;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Infect Dis Epidemiol, London W2 1PG, England Univ London Imperial Coll Sci Technol & Med London England W2 1PG ngland Univ Oxford, Wellcome Trust Ctr Epidemiol Infect Dis, Oxford OX1 2JD, England Univ Oxford Oxford England OX1 2JD l Infect Dis, Oxford OX1 2JD, England Abbott Labs, Abbott Pk, IL 60064 USA Abbott Labs Abbott Pk IL USA 60064Abbott Labs, Abbott Pk, IL 60064 USA
Titolo Testata:
AIDS
fascicolo: 9, volume: 15, anno: 2001,
pagine: 1133 - 1142
SICI:
0269-9370(20010615)15:9<1133:COTEON>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRUS TYPE-1 RNA; PLASMA HIV RNA; ANTIRETROVIRAL THERAPY; CLINICAL-TRIALS; LYMPHOCYTE COUNTS; RANDOMIZED TRIALS; CUBIC MILLIMETER; PLUS INDINAVIR; INFECTION; EFFICACY;
Keywords:
HIV-1; AIDS; antiretroviral therapy; protease inhibitors; non-nucleoside reverse transcriptase inhibitors; observational databases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Ghani, AC Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Infect Dis Epidemiol, Norfolk Pl, London W2 1PG, England Univ London Imperial Coll Sci Technol & Med Norfolk Pl London England W2 1PG
Citazione:
A.C. Ghani et al., "Comparison of the effectiveness of non-nucleoside reverse transcriptase inhibitor-containing and protease inhibitor-containing regimens using observational databases", AIDS, 15(9), 2001, pp. 1133-1142

Abstract

Objectives: To compare the effectiveness of first protease inhibitor (PI)-containing and non-nucleoside reverse transcriptase inhibitor (NNRTI)-containing regimens. Methods: Data were analysed from three large HIV patient databases: ApacheHIV Insight (TM) (APACHE), Target Management Services (TMS) and Clinical Partners (CP). The effectiveness of therapy was the time taken for HIV-1 RNAto fall below detectable levels on first highly active antiretroviral therapy regimen (Pl- or NNRTI-containing) and the subsequent time to failure (two consecutive delectable measurements). Comparisons were made using proportional hazards models, adjusting for differences in age, sex, previous reverse transcriptase inhibitor use, calendar year and baseline viral load and CD4 T-cell count. Results: The type of regimen was not associated with time to undetectable viral load in any of the three databases, all of which had high power to detect a difference. Pl-containing regimens were significantly less likely tofail after reaching undetectable viral loads for APACHE and CP patients (relative hazard, 1.7; 95% confidence interval, 1.3-2.1 and relative hazard, 1.6; 95% confidence interval, 1.0-2.5 respectively). These results remainedsignificant after allowing for an unmeasured confounder with moderate effect on risk. No significant association between time to failure and regimen was found for TMS patients, possibly due to low power (67% to detect a relative hazard of 1.5). No difference was found between regimens in the time taken for an increase of > 100 X 10(9) cells/l in CD4 T-cell count. In the APACHE database, those on NNRTI-containing regimens were more likely to havea failing CD4 T-cell response. Conclusions: PI-containing regimens have a lower risk of treatment failurethan NNRTI-containing regimens. (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 06/04/20 alle ore 01:08:38