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Titolo:
Eccentric muscle damage: mechanisms of early reduction of force
Autore:
Allen, DG;
Indirizzi:
Univ Sydney, Dept Physiol, Sydney, NSW 2006, Australia Univ Sydney SydneyNSW Australia 2006 hysiol, Sydney, NSW 2006, Australia Univ Sydney, Inst Biomed Res F13, Sydney, NSW 2006, Australia Univ SydneySydney NSW Australia 2006 es F13, Sydney, NSW 2006, Australia
Titolo Testata:
ACTA PHYSIOLOGICA SCANDINAVICA
fascicolo: 3, volume: 171, anno: 2001,
pagine: 311 - 319
SICI:
0001-6772(200103)171:3<311:EMDMOE>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTRACTION-INDUCED INJURY; MOUSE SKELETAL-MUSCLE; INTRACELLULAR CALCIUM; LENGTHENING CONTRACTIONS; CELLULAR MECHANISMS; SOLEUS MUSCLE; MDX MICE; EXERCISE; FIBERS; STRETCH;
Keywords:
cytoskeletal proteins; eccentric contraction; muscle damage; reduced force; sarcomere disorganization; skeletal muscle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Allen, DG Univ Sydney, Dept Physiol, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 dney, NSW 2006, Australia
Citazione:
D.G. Allen, "Eccentric muscle damage: mechanisms of early reduction of force", ACT PHYSL S, 171(3), 2001, pp. 311-319

Abstract

Pain and weakness are prominent symptoms which occur after a delay in muscles which have been stretched during contraction (eccentric contraction). These symptoms are particularly severe when the exercise is unaccustomed andwhen the stretch occurs in muscles on the descending limb of the force-length relation, i.e, at long muscle lengths. it is known that sarcomeres are potentially unstable on the descending limb and it has been proposed by Morgan that uncontrolled elongation of some sarcomeres occurs during eccentriccontractions on the descending limb. In this article, the evidence that this mechanism leads to the reduced force is considered. if overextended sarcomeres persist after the eccentric exercise it will cause a shift in the peak of the force-length curve. There is also evidence that in some types of muscle, excitation-contraction coupling is impaired and contributes to the muscle weakness. Cytoskeletal proteins stabilize the sarcomeric structure and may be injured either by the overextended sarcomeres or by activation ofproteases. The potential of these mechanisms to contribute to the effects of muscle training and to the symptoms of muscle disease, such as muscular dystrophy, is considered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 22:33:00