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Titolo:
The efficacy of bismuth subsalicylate in the treatment of acute diarrhoea and the prevention of persistent diarrhoea
Autore:
Chowdhury, HR; Yunus, M; Zaman, K; Rahman, A; Faruque, SM; Lescano, AG; Sack, RB;
Indirizzi:
Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 t Hlth, Baltimore, MD 21205 USA Int Ctr Diarrhoeal Dis Res, Publ Hlth Sci Div, Dhaka 1000, Bangladesh Int Ctr Diarrhoeal Dis Res Dhaka Bangladesh 1000 Dhaka 1000, Bangladesh
Titolo Testata:
ACTA PAEDIATRICA
fascicolo: 6, volume: 90, anno: 2001,
pagine: 605 - 610
SICI:
0803-5253(200106)90:6<605:TEOBSI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BANGLADESHI CHILDREN; THERAPY; DISEASE; AGE;
Keywords:
acute diarrhoea; bismuth subsalicylate; nutrition; persistent diarrhoea;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Sack, RB Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Int Hlth, 624 N Broadway, Baltimore, MD 21205 USA Johns Hopkins Univ 624 N Broadway Baltimore MD USA 21205 1205 USA
Citazione:
H.R. Chowdhury et al., "The efficacy of bismuth subsalicylate in the treatment of acute diarrhoea and the prevention of persistent diarrhoea", ACT PAEDIAT, 90(6), 2001, pp. 605-610

Abstract

A controlled, randomized, double-blind study in Bangladeshi children (ages4-36 mo) with acute diarrhoea was undertaken to determine whether bismuth subsalicylate (BSS) would prevent the development of persistent diarrhoea (PD) in young children. The children were randomized to two groups: 226 weregiven liquid oral BSS, las Pepto-Bismol), 100 mg/kg/d for 5 d; 225 were given placebo of identical appearance. On admission to the study, the two groups were comparable both clinically and microbiologically. Rotavirus was found in 56% of all the children, and enterotoxigenic E. coli in 31% of a subsample studied. Children treated with BSS had less severe and less prolonged illness than those treated with placebo (p = 0.057). There was, however, no difference in the development of PD between the two groups (8% and 11%). Unexpectedly, patients treated with BSS gained significantly more weight (2.3%) than those treated with placebo (0.5% : p < 0.001) during the course of the study. No toxicity of BSS was detected. Conclusion: Treatment with BSS had a modest therapeutic effect on acute diarrhoea, as has been previously demonstrated, but with no suggestion of a therapeutic effect on the prevention of persistent diarrhoea in this group of patients.

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Documento generato il 05/04/20 alle ore 04:09:18