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Titolo:
First outbreak of callitrichid hepatitis in Germany: Genetic characterization of the causative lymphocytic choriomeningitis virus strains
Autore:
Asper, M; Hofmann, P; Osmann, C; Funk, J; Metzger, C; Bruns, M; Kaup, FJ; Schmitz, H; Gunther, S;
Indirizzi:
Bernhard Nocht Inst Trop Med, D-20359 Hamburg, Germany Bernhard Nocht InstTrop Med Hamburg Germany D-20359 59 Hamburg, Germany Deutsch Primatenzentrum, Gottingen, Germany Deutsch Primatenzentrum Gottingen Germany enzentrum, Gottingen, Germany Zoo Dortmund, Dortmund, Germany Zoo Dortmund Dortmund GermanyZoo Dortmund, Dortmund, Germany Univ Giessen, Inst Vet Pathol, Giessen, Germany Univ Giessen Giessen Germany Giessen, Inst Vet Pathol, Giessen, Germany Labor Prof Enders & Partner, Stuttgart, Germany Labor Prof Enders & Partner Stuttgart Germany rtner, Stuttgart, Germany Univ Hamburg, Heinrich Pette Inst Expt Virol & Immunol, D-2000 Hamburg, Germany Univ Hamburg Hamburg Germany D-2000 l & Immunol, D-2000 Hamburg, Germany
Titolo Testata:
VIROLOGY
fascicolo: 2, volume: 284, anno: 2001,
pagine: 203 - 213
SICI:
0042-6822(20010605)284:2<203:FOOCHI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR CHARACTERIZATION; NEUTRALIZING ANTIBODY; VIRAL PERSISTENCE; LASSA FEVER; IN-VIVO; SEQUENCE; SELECTION; MARMOSETS; VARIANTS; TAMARINS;
Keywords:
callitrichid hepatitis; pygmy marmoset; Goeldi's monkey; lymphocytic choriomeningitis virus; arenavirus; phylogeny; sequence; pathology; histology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Gunther, S Bernhard Nocht Inst Trop Med, Bernhard Nocht Str 74, D-20359 Hamburg, Germany Bernhard Nocht Inst Trop Med Bernhard Nocht Str 74 Hamburg Germany D-20359
Citazione:
M. Asper et al., "First outbreak of callitrichid hepatitis in Germany: Genetic characterization of the causative lymphocytic choriomeningitis virus strains", VIROLOGY, 284(2), 2001, pp. 203-213

Abstract

Callitrichid hepatitis (CH) is a highly fatal, rodent-borne zoonosis of New world primates (family Callitrichidae) caused by lymphocytic choriomeningitis virus (LCMV). It is unclear whether virulence in Callitrichidae is associated with specific genetic or phylogenetic markers of the virus as only a partial S RNA sequence of a single CH-associated isolate is known. in a period of 10 months, three pygmy marmosets (Cebuella pygmaea) and one Goeldi's monkey (Callimico goeldii) died from CH in a German zoo. LCMV was most likely transmitted by wild mice. infection was associated with characteristic histopathological lesions in liver, brain, and lymphoid tissue. Virus sequences from all callitrichids and a captured mouse were greater than or equal to 99.2% identical. LCMV strains from a pygmy marmoset and the Goeldi's monkey were isolated in cell culture and the 3.4-kb S RNA was completely sequenced. Both strains differed considerably in their genetic and phylogenetic characteristics from known LCMV strains, including the previously described CH-associated strain. These data show that CH is widespread and can be caused by distantly related LCMV strains. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:45:25