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Titolo:
Effect of pre-existing immunity for systemic and mucosal immune responses to intranasal immunization with group B Streptococcus type III capsular polysaccharide-cholera toxin B subunit conjugate
Autore:
Shen, XZ; Lagergard, T; Yang, YH; Lindblad, M; Fredriksson, M; Wallerstrom, G; Holmgren, J;
Indirizzi:
Univ Gothenburg, Dept Med Microbiol & Immunol, SE-41346 Gothenburg, SwedenUniv Gothenburg Gothenburg Sweden SE-41346 , SE-41346 Gothenburg, Sweden Capital Univ Med Sci, Beijing Childrens Hosp, Beijing 100045, Peoples R China Capital Univ Med Sci Beijing Peoples R China 100045 045, Peoples R China
Titolo Testata:
VACCINE
fascicolo: 25-26, volume: 19, anno: 2001,
pagine: 3360 - 3368
SICI:
0264-410X(20010514)19:25-26<3360:EOPIFS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN CONJUGATE; ANTIBODY-RESPONSE; C POLYSACCHARIDE; GAMBIAN CHILDREN; VACCINES; IMMUNOGENICITY; ANTIGEN; SECRETIONS; INFANCY; MICE;
Keywords:
GBS CPSIII-rCTB conjugate; group B Streptococcus; pre-existing immunity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Lagergard, T Univ Gothenburg, Dept Med Microbiol & Immunol, Guldhedsgatan 10, SE-41346 Gothenburg, Sweden Univ Gothenburg Guldhedsgatan 10 Gothenburg Sweden SE-41346
Citazione:
X.Z. Shen et al., "Effect of pre-existing immunity for systemic and mucosal immune responses to intranasal immunization with group B Streptococcus type III capsular polysaccharide-cholera toxin B subunit conjugate", VACCINE, 19(25-26), 2001, pp. 3360-3368

Abstract

The effects of priming with a group B Streptococcus type III capsular polysaccharide (GBS CPS III)-recombinant cholera toxin B subunit (rCTB) conjugate, purified GBS CPS III or rCTB alone on the systemic and mucosal immune responses to CPS III after intranasal (i.n.) immunization were investigated in mice. Priming with purified GBS CPS III followed by boosting with GBS CPS III-rCTB conjugate or priming with the conjugate followed by boosting with foe CPS induced comparable levels of specific IgG and IgA in both serum and in lungs and vagina. However, i.n. immunization comprising both priming and boosting with conjugate was superior to priming with CPS and boosting with conjugate or the reverse, especially with regard to inducing mucosal IgA anti-CPS responses. All the immunization schemes, except priming and boosting with free CPS, induced high and similar levels of IgG1 in serum. In contrast, mice primed with free CPS III and then boosted with CPS III-rCTB conjugate by the i.n. route failed to produce significant levels of IgG2a, IgG2b and IgG3 in serum, at difference from mice primed with the conjugate and boosted with either conjugate or free CPS. Pre-immunization with rCTB either i.n. or i.p. did nut suppress specific serum IgG responses induced by GBS CPS III-rCTB conjugate intranasally, but did inhibit serum and especially mucosal IgA responses. Our findings suggest that priming with CPS affectsthe distribution of IgG subclasses to GBS CPS and that pre-existing anti-carrier rCTB immunity can have an inhibitory effect on mucosal immune responses elicited by the conjugate vaccine given by the i.n. route. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:49:48