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Titolo:
Live attenuated vaccines against influenza; an historical review
Autore:
Wareing, MD; Tannock, GA;
Indirizzi:
RMIT Univ, Dept Biotechnol & Environm Biol, Bundoora, Vic 3083, Australia RMIT Univ Bundoora Vic Australia 3083 Biol, Bundoora, Vic 3083, Australia
Titolo Testata:
VACCINE
fascicolo: 25-26, volume: 19, anno: 2001,
pagine: 3320 - 3330
SICI:
0264-410X(20010514)19:25-26<3320:LAVAIA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
WILD-TYPE VIRUS; A VIRUS; YOUNG-CHILDREN; COLD-RECOMBINANT; ADULT VOLUNTEERS; DOSE-RESPONSE; REASSORTANT VIRUSES; SEQUENCE CHANGES; TRIVALENT; H3N2;
Keywords:
live vaccines; influenza; development;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Tannock, GA RMIT Univ, Dept Biotechnol & Environm Biol, POB 71, Bundoora, Vic 3083, Australia RMIT Univ POB 71 Bundoora Vic Australia 3083 c 3083, Australia
Citazione:
M.D. Wareing e G.A. Tannock, "Live attenuated vaccines against influenza; an historical review", VACCINE, 19(25-26), 2001, pp. 3320-3330

Abstract

Live attenuated vaccines administered directly to the respiratory tract offer the promise of providing more effective immunity against influenza thansubunit or split inactivated vaccines. Evidence has accumulated in recent years that immunological responses relevant to both the prevention of and recovery from influenza are brat induced by natural infection. The ease withwhich the genes of influenza viruses reassert when two or more viruses infect a single cell has been exploited as a means of rapidly producing attenuated vaccines. Donor strains that have been shown by extensive testing to be fully attenuated are used to co-infect cells with contemporary epidemic strains to produce reassortants with the required degree of avirulence and the surface antigens of the epidemic strain. Reassortants prepared from cold-adapted mutants of both influenza A and B viruses have been widely shown from clinical trials in both the United States and Russia over many years tobe well tolerated in both adults and children and to be highly efficacious. (C) 2001 Elsevier Science Ltd. All rights: reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 03:02:03