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Titolo:
Neurovascular coupling in terms of a control system: Validation of a second-order linear system model
Autore:
Rosengarten, B; Huwendiek, O; Kaps, M;
Indirizzi:
Univ Giessen, Fac Med, Dept Neurol, Giessen, Germany Univ Giessen Giessen Germany en, Fac Med, Dept Neurol, Giessen, Germany Univ Lubeck, Dept Tech Informat, Lubeck, Germany Univ Lubeck Lubeck Germany Lubeck, Dept Tech Informat, Lubeck, Germany
Titolo Testata:
ULTRASOUND IN MEDICINE AND BIOLOGY
fascicolo: 5, volume: 27, anno: 2001,
pagine: 631 - 635
SICI:
0301-5629(200105)27:5<631:NCITOA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; OXIDATIVE-METABOLISM; VELOCITY;
Keywords:
cerebral blood flow; transcranial Doppler sonography; diagnostic imaging; metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Kaps, M Steg 14, D-35385 Giessen, Germany Steg 14 Giessen Germany D-35385 teg 14, D-35385 Giessen, Germany
Citazione:
B. Rosengarten et al., "Neurovascular coupling in terms of a control system: Validation of a second-order linear system model", ULTRASOUN M, 27(5), 2001, pp. 631-635

Abstract

Neurovascular coupling (NC) adapts cerebral blood flow to cortical activity. Functional transcranial Doppler (f-TCD) investigations revealed a typical time course of evoked blood how responses with an initial overshoot and astabilization at a lower, but stable, level, This blood Bow reaction can be described in terms of a control-system model, We tested reliability and validity of this new approach using different stimulation paradigms, The P2 segment of the posterior cerebral artery was insonated in 14 healthy volunteers and, subsequently, NC was stimulated using two tests, a checkerboard stimulus of 1 s with different repetition rates and a reading test. Data were analyzed according to algorithms of control-system theory. The reading test was used to measure test reliability and side differences, A second-order linear system can describe blood flow regulation of NC. Different stimulation protocols of the checkerboard test and the related evoked blood flow curves could he described by the same control-system model. Further, there were no differences between the checkerboard and reading test nor between right and Left side or test and retest of the reading test, NC can be described in a much more detailed manner using control-system analysis. We were able to show that blood flow response due to different visual stimuli follow one common control-system model. Unlike quantification of NC using overshoot, parameters of the control system have smaller SDs, increasing the statistical power and, thereby, usefulness: of f-TCD as a diagnostic instrument. (E-mail: Manfred.Kaps @ Neuro.med.uni-Giessen.de) (C) 2001 World Federationfor Ultrasound in Medicine & Biology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:17:04