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Titolo:
Platelet transfusions in the neonatal intensive care unit: factors predicting which patients will require multiple transfusions
Autore:
Del Vecchio, A; Sola, MC; Theriaque, DW; Hutson, AD; Kao, KJ; Wright, D; Garcia, MG; Pollock, BH; Christensen, RD;
Indirizzi:
Univ Florida, Coll Med, Div Neonatol, Dept Pediat, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 t Pediat, Gainesville, FL 32610 USA Univ Florida, Coll Med, Dept Pathol, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 t Pathol, Gainesville, FL 32610 USA Univ Florida, Coll Med, Dept Hlth Policy & Epidemiol, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 pidemiol, Gainesville, FL 32610 USA Univ Florida, Coll Med, Gen Clin Res Ctr, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 Res Ctr, Gainesville, FL 32610 USA
Titolo Testata:
TRANSFUSION
fascicolo: 6, volume: 41, anno: 2001,
pagine: 803 - 808
SICI:
0041-1132(200106)41:6<803:PTITNI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MEGAKARYOCYTE GROWTH; RECOMBINANT HUMAN THROMBOPOIETIN; NONHUMAN-PRIMATES; LIVER-CIRRHOSIS; PRETERM BABIES; RISK-FACTORS; BONE-MARROW; HUMAN FETAL; THROMBOCYTOPENIA; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Sola, MC Univ Florida, Coll Med, Div Neonatol, Dept Pediat, POB 100296, Gainesville, FL 32610 USA Univ Florida POB 100296 Gainesville FL USA 32610 le, FL 32610 USA
Citazione:
A. Del Vecchio et al., "Platelet transfusions in the neonatal intensive care unit: factors predicting which patients will require multiple transfusions", TRANSFUSION, 41(6), 2001, pp. 803-808

Abstract

BACKGROUND: Previous studies suggest that recombinant thrombopoietin (rTPO) will increase platelet production in thrombocytopenic neonates. However, the target populations of neonates most likely to benefit should be defined. Studies suggest that rTPO will not elevate the platelet count until 5 days after the start of treatment. Therefore; the neonates who might benefit from rTPO are those who will require multiple platelet transfusions for morethan 5 days. This study was designed to find means of prospectively identifying these patients. STUDY DESIGN AND METHODS: A historic cohort study of all patients in the neonatal intensive care unit (NICU) at the University of Florida who received platelet transfusions from January 1, 1997, through December 31, 1998, was conducted. RESULTS: Of the 1389 patients admitted to the NICU during the study period, 131 (9.4%) received platelet transfusions. Seventeen were treated with extracorporeal membrane oxygenation and were excluded from further analysis. Of the remaining 114 patients, 55 (48%) received one transfusion and 59 (52%) received more than one transfusion (21 had >4). None of the demographic factors examined predicted multiple platelet transfusions. However, two clinical conditions did; liver disease and renal insufficiency Neonates who received one platelet transfusion had a relative risk of death 10.4 times that in neonates who received none (p = 0.0001). Neonates who received >4 platelet transfusions had a risk of death 29.9 times that in those who receivedno transfusions (p = 0.0001). CONCLUSION: NICU patients with liver disease or renal insufficiency who receive one platelet transfusion are likely to receive additional transfusions. Therefore, these patients constitute a possible study population for a Phase I/II rTPO trial.

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Documento generato il 24/01/20 alle ore 13:31:21