Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Inhaled naphthalene causes dose dependent Clara cell cytotoxicity in mice but not in rats
Autore:
West, JAA; Pakehham, G; Morin, D; Fleschner, CA; Buckpitt, AR; Plopper, CG;
Indirizzi:
Univ Calif Davis, Sch Vet Med, Dept Anat Physiol & Cell Biol, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 siol & Cell Biol, Davis, CA 95616 USA Univ Calif Davis, Sch Vet Med, Dept Mol Biosci, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Dept Mol Biosci, Davis, CA 95616 USA
Titolo Testata:
TOXICOLOGY AND APPLIED PHARMACOLOGY
fascicolo: 2, volume: 173, anno: 2001,
pagine: 114 - 119
SICI:
0041-008X(20010601)173:2<114:INCDDC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOCHROME-P450 ACTIVITY; LUNG; METABOLISM; MOUSE; COUMARIN; HAMSTERS; TOXICITY; AIRWAYS; INJURY;
Keywords:
respiratory; epithelium; toxicity; naphthalene; mice; Clara cell toxicity; dose dependence; morphometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: West, JAA Univ Calif Davis, Sch Vet Med, Dept Anat Physiol & Cell Biol, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 l Biol, Davis, CA 95616 USA
Citazione:
J.A.A. West et al., "Inhaled naphthalene causes dose dependent Clara cell cytotoxicity in mice but not in rats", TOX APPL PH, 173(2), 2001, pp. 114-119

Abstract

Current OSHA standards for naphthalene exposure are set at 10 ppm (time-weighted average) with a standard threshold exposure concentration of 15 ppm. While several studies have thoroughly delineated the time course and dose response of injury by naphthalene administered ip, the pattern and severityof injury by inhalation exposure are unknown. These studies compare the regiospecific and dose-dependent cytotoxicity of naphthalene after inhalationexposure. Mice and rats were exposed for 4 h to naphthalene vapor at concentrations of 0-110 ppm. In rats, no injury was observed in the lung epithelium at exposure concentrations up to 100 ppm. Exposures as low as 2 ppm produced proximal airway injury in mice, with increased severity in a concentration-dependent fashion up to 75 ppm. Terminal airways of exposed mice exhibited little or no injury at low concentrations (1-3 ppm). Exposures of 8.5ppm or higher were required to produce injury to Clara cells in the terminal airways. In contrast, administration of naphthalene (less than or equal to 200 mg/kg ip) caused Clara cell cytotoxicity, which was limited to distal airways in mice. Higher doses (> 300 mg/kg) extended the injury pattern toward the lobar bronchus. We conclude (1) the pattern of injury to naphthalene is highly dependent on the route of exposure, (2) lung injury to inhaled naphthalene is species dependent, and (3) Clara cells of mouse airways are exquisitely sensitive to inhaled naphthalene at concentrations well belowthe current OSHA standard for human exposure. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 00:09:15