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Titolo:
Toxicity of Fusarium moniliforme culture material containing known levels of fumonisin B1 in ducks
Autore:
Bailly, JD; Benard, G; Jouglar, JY; Durand, S; Guerre, P;
Indirizzi:
Sch Vet, Mycotoxicol Lab, F-31076 Toulouse, France Sch Vet Toulouse France F-31076 ycotoxicol Lab, F-31076 Toulouse, France
Titolo Testata:
TOXICOLOGY
fascicolo: 1, volume: 163, anno: 2001,
pagine: 11 - 22
SICI:
0300-483X(20010528)163:1<11:TOFMCM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY RAT HEPATOCYTES; HUMAN ESOPHAGEAL CANCER; PROTEIN-KINASE-C; LIVER IN-VIVO; BROILER CHICKS; LIPID-PEROXIDATION; DNA-DAMAGE; HIGH-RISK; B-1; CORN;
Keywords:
fumonisin; toxicity; duck; liver;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Guerre, P Sch Vet, Mycotoxicol Lab, 23 Chemin Capelles, F-31076 Toulouse, France Sch Vet 23 Chemin Capelles Toulouse France F-31076 ouse, France
Citazione:
J.D. Bailly et al., "Toxicity of Fusarium moniliforme culture material containing known levels of fumonisin B1 in ducks", TOXICOLOGY, 163(1), 2001, pp. 11-22

Abstract

Fusarium moniliforme culture material toxicity containing fumonisin B1 (FBI) was investigated into four groups of five growing ducks, each receiving 0, 5, 15 or 45 mg/kg FB1 by daily oral administration over 12 days. Treatments did not lead to lethality. but the average body weight gain was slightly retarded in treated versus control animals. without apparent dose relation. A dose-dependant increase of thr liver weight with a disorganization of the span and implementation of a microglandular structure in both periportal and centrolobular areas was obtained. In the plasma, together protein. cholesterol. alanine aminotransferase. lactate dehydrogenase, gammaglutamyl tranferase and sphinganine to sphingosine ratio (SA/SO) were increased. No sign of apoptosis was present neither in the liver nor in peripheral blood lymphocytes and only moderate oxidative damages were obtained. These resultsare of interest, because although FB1 increases SA/SO and is hepatotoxic in all investigated species, liver hyperplasia with increased liver weight were obtained in ducks. whereas decreased liver weight and apoptosis are observed in rats. Finally. although ducks appeared resistant to FB1 toxicity in terms of mortality, liver alterations were obtained with only 5 mg/kg perday of FB I for 12 days. Considering the fact that high levels of FBI mag;occur in corn (100-300 mg/kg) liver pathology could have an impact in farming conditions. (C) 2001 Elsevier Science Ireland Ltd, All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 18:43:48