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Titolo:
Diastereoselective hydroformylation of Delta(4)-steroids with rhodium-phosphite catalysts
Autore:
Freixa, Z; Pereira, MM; Bayon, JC; Silva, AMS; Salvador, JAR; Beja, AM; Paixao, JA; Ramos, M;
Indirizzi:
Univ Coimbra, Dept Quim, P-3049 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3049 Dept Quim, P-3049 Coimbra, Portugal Univ Autonoma Barcelona, Dept Quim, E-08193 Barcelona, Spain Univ AutonomaBarcelona Barcelona Spain E-08193 E-08193 Barcelona, Spain Univ Aveiro, Dept Quim, P-3810193 Aveiro, Portugal Univ Aveiro Aveiro Portugal P-3810193 t Quim, P-3810193 Aveiro, Portugal Univ Coimbra, Fac Farm, P-3049 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3049 Fac Farm, P-3049 Coimbra, Portugal Univ Coimbra, Dept Fis, P-3049 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3049 Dept Fis, P-3049 Coimbra, Portugal
Titolo Testata:
TETRAHEDRON-ASYMMETRY
fascicolo: 7, volume: 12, anno: 2001,
pagine: 1083 - 1087
SICI:
0957-4166(20010508)12:7<1083:DHODWR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOMOGENEOUS CATALYSIS; BULKY PHOSPHITE; STEROIDS; CARBONYLATION; DERIVATIVES; SKELETON; OLEFINS; FORMYL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Pereira, MM Univ Coimbra, Dept Quim, Rua Larga, P-3049 Coimbra, Portugal Univ Coimbra Rua Larga Coimbra Portugal P-3049 mbra, Portugal
Citazione:
Z. Freixa et al., "Diastereoselective hydroformylation of Delta(4)-steroids with rhodium-phosphite catalysts", TETRAHEDR-A, 12(7), 2001, pp. 1083-1087

Abstract

The hydroformylation of two steroidal substrates, namely 17 beta -acetoxyandrost-4-ene 1 and 3 beta, 17 beta -diacetoxyandrost-4-ene 2, with a rhodium tris(O-tert-butylphenyl)phosphite catalyst was investigated. In both cases, the major reaction product was 4 beta -formyl-17 beta -acetoxy-5 beta -androstane 3, which was isolated and characterized by X-ray diffraction and NMR techniques. This reaction is the first example of catalytic carbonylation to the beta face of a steroid backbone. The effect of reaction temperature, the pressure at which the reaction was completed and the ligand:Rh ratio on the regio- and stereoselectivity of the reaction is also discussed. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 12:41:27