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Titolo:
COMPARATIVE EFFICACY OF THE INTRAVENOUS ADMINISTRATION OF LINSIDOMINE, A DIRECT NITRIC-OXIDE DONOR, AND ISOSORBIDE DINITRATE IN SEVERE UNSTABLE ANGINA - A FRENCH MULTICENTER STUDY
Autore:
DELONCA J; GIRAUD T; BEAUFILS P; DUPUIS B; HAIAT R; THERY C;
Indirizzi:
HOP LARIBOISIERE,SERV CARDIOL,2 RUE AMBROISE PARE F-75475 PARIS 10 FRANCE HOP LARIBOISIERE,SERV CARDIOL F-75475 PARIS 10 FRANCE LABS HOECHST,DEPT CARDIOVASC PARIS FRANCE CTR HOSP REG & UNIV LILLE,SERV PHARMACOL F-59037 LILLE FRANCE CTR HOSP GEN,SERV CARDIOL ST GERMAIN LAYE FRANCE CTR HOSP REG & UNIV LILLE,UNITE SOINS INTENSIFS CARDIOL F-59037 LILLEFRANCE
Titolo Testata:
European heart journal
fascicolo: 8, volume: 18, anno: 1997,
pagine: 1300 - 1306
SICI:
0195-668X(1997)18:8<1300:CEOTIA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITROGLYCERIN; INFUSION; PECTORIS; ISCHEMIA; TOLERANCE; DISEASE; DEATH;
Keywords:
UNSTABLE ANGINA; LINSIDOMINE; ISOSORBIDE DINITRATE; HOLTER MONITORING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
J. Delonca et al., "COMPARATIVE EFFICACY OF THE INTRAVENOUS ADMINISTRATION OF LINSIDOMINE, A DIRECT NITRIC-OXIDE DONOR, AND ISOSORBIDE DINITRATE IN SEVERE UNSTABLE ANGINA - A FRENCH MULTICENTER STUDY", European heart journal, 18(8), 1997, pp. 1300-1306

Abstract

Aims Although, linsidomine shares common properties with nitrovasodilators, it releases nitric oxide directly without catalytic involvementby thiols. We conducted a prospective, randomized, multicentre, parallel group, single-blind study to compare the efficacy of intravenous administration of linsidomine with that of isosorbide dinitrate in unstable angina. Methods and results Between November 1990 and July 1992, 568 patients with suspected unstable angina (class IIIB of the Braunwald classification) received a continuous infusion of either linsidomine (1 mg.h(-1) on average) or isosorbide dinitrate (2.5 mg.h(-1) on average) for 72 h. All patients received concomitant aspirin and intravenous heparin, 81% beta-blockers and 38% calcium antagonists. Holter monitoring was performed in all patients and analysed blindly. Only 25% of the patients had at least one episode of chest pain during the study(24.6% vs 25.8% in the linsidomine and isosorbide dinitrate groups, P=0.74), of which 12% were associated with ECG changes. Holter criteriayielded similar results in both groups: 33% of patients presented episodes of myocardial ischaemia (32.6% vs 33.9% in the linsidomine and isosorbide dinitrate groups, P=0.74), while 45% showed episodes of ventricular arrhythmia (43.5% vs 46.5% in the linsidomine and isosorbide dinitrate groups, P=0.48). The incidence of serious clinical events at 72 h (death, myocardial infarction or myocardial revascularization) was 6.5% (5% vs 8% in the linsidomine and isosorbide dinitrate groups, P=0.17). Conclusion Intravenous linsidomine is at least as efficacious as isosorbide dinitrate in the stabilization of patients with severe unstable angina.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 00:44:34